Effects of repeated skin exposure to low nickel concentrations: a model for allergic contact dermatitis to nickel on the hands
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Effects of repeated skin exposure to low nickel concentrations : a model for allergic contact dermatitis to nickel on the hands. / Nielsen, N H; Menné, T; Kristiansen, J; Christensen, J M; Borg, L; Poulsen, L K.
I: British Journal of Dermatology. Supplement, Bind 141, Nr. 4, 10.1999, s. 676-82.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of repeated skin exposure to low nickel concentrations
T2 - a model for allergic contact dermatitis to nickel on the hands
AU - Nielsen, N H
AU - Menné, T
AU - Kristiansen, J
AU - Christensen, J M
AU - Borg, L
AU - Poulsen, L K
PY - 1999/10
Y1 - 1999/10
N2 - We studied the effects of repeated daily exposure to low nickel concentrations on the hands of patients with hand eczema and nickel allergy. The concentrations used were chosen to represent the range of trace to moderate occupational nickel exposure. The study was double-blinded and placebo controlled. Patients immersed a finger for 10 min daily into a 10-p.p.m. nickel concentration in water for the first week, and during the second week into a 100-p.p.m. nickel concentration. This regimen significantly increased (P = 0.05) local vesicle formation and blood flow (P = 0.03) as compared with a group of patients who immersed a finger into water. The nickel concentrations used also provoked significant inflammatory skin changes on sodium lauryl sulphate (SLS)-treated forearm skin of the patients, whereas inflammatory skin changes were not observed in healthy volunteers without hand eczema and nickel allergy, either on normal or on SLS-treated forearm skin. The present study strongly suggests that the changes observed were specific to nickel exposure. Standardized methods to assess trace to moderate nickel exposure on the hands, and the associated effects in nickel-sensitized subjects, are needed.
AB - We studied the effects of repeated daily exposure to low nickel concentrations on the hands of patients with hand eczema and nickel allergy. The concentrations used were chosen to represent the range of trace to moderate occupational nickel exposure. The study was double-blinded and placebo controlled. Patients immersed a finger for 10 min daily into a 10-p.p.m. nickel concentration in water for the first week, and during the second week into a 100-p.p.m. nickel concentration. This regimen significantly increased (P = 0.05) local vesicle formation and blood flow (P = 0.03) as compared with a group of patients who immersed a finger into water. The nickel concentrations used also provoked significant inflammatory skin changes on sodium lauryl sulphate (SLS)-treated forearm skin of the patients, whereas inflammatory skin changes were not observed in healthy volunteers without hand eczema and nickel allergy, either on normal or on SLS-treated forearm skin. The present study strongly suggests that the changes observed were specific to nickel exposure. Standardized methods to assess trace to moderate nickel exposure on the hands, and the associated effects in nickel-sensitized subjects, are needed.
KW - Adult
KW - Aged
KW - Case-Control Studies
KW - Dermatitis, Allergic Contact
KW - Dermatitis, Occupational
KW - Double-Blind Method
KW - Forearm
KW - Hand Dermatoses
KW - Humans
KW - Middle Aged
KW - Nickel
KW - Patch Tests
KW - Regional Blood Flow
KW - Statistics, Nonparametric
KW - Clinical Trial
KW - Journal Article
KW - Randomized Controlled Trial
KW - Research Support, Non-U.S. Gov't
U2 - 10.1046/j.1365-2133.1999.03106.x
DO - 10.1046/j.1365-2133.1999.03106.x
M3 - Journal article
C2 - 10583115
VL - 141
SP - 676
EP - 682
JO - British Journal of Dermatology, Supplement
JF - British Journal of Dermatology, Supplement
SN - 0366-077X
IS - 4
ER -
ID: 169716127