Effects of exposure imprecision on estimation of the benchmark dose
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Effects of exposure imprecision on estimation of the benchmark dose. / Budtz-Jørgensen, Esben; Keiding, Niels; Grandjean, Philippe.
I: Risk Analysis, Bind 24, Nr. 6, 2004, s. 1689-96.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of exposure imprecision on estimation of the benchmark dose
AU - Budtz-Jørgensen, Esben
AU - Keiding, Niels
AU - Grandjean, Philippe
N1 - Keywords: Algorithms; Child; Confidence Intervals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Female; Humans; Maternal Exposure; Mercury; Models, Statistical; Models, Theoretical; No-Observed-Adverse-Effect Level; Pregnancy; Prenatal Exposure Delayed Effects; Probability; Regression Analysis; Research Design; Risk; Risk Assessment; Sample Size; Sensitivity and Specificity; Software; Statistics as Topic
PY - 2004
Y1 - 2004
N2 - In regression analysis failure to adjust for imprecision in the exposure variable is likely to lead to underestimation of the exposure effect. However, the consequences of exposure error for determination of safe doses of toxic substances have so far not received much attention. The benchmark approach is one of the most widely used methods for development of exposure limits. An important advantage of this approach is that it can be applied to observational data. However, in this type of data, exposure markers are seldom measured without error. It is shown that, if the exposure error is ignored, then the benchmark approach produces results that are biased toward higher and less protective levels. It is therefore important to take exposure measurement error into account when calculating benchmark doses. Methods that allow this adjustment are described and illustrated in data from an epidemiological study on the health effects of prenatal mercury exposure.
AB - In regression analysis failure to adjust for imprecision in the exposure variable is likely to lead to underestimation of the exposure effect. However, the consequences of exposure error for determination of safe doses of toxic substances have so far not received much attention. The benchmark approach is one of the most widely used methods for development of exposure limits. An important advantage of this approach is that it can be applied to observational data. However, in this type of data, exposure markers are seldom measured without error. It is shown that, if the exposure error is ignored, then the benchmark approach produces results that are biased toward higher and less protective levels. It is therefore important to take exposure measurement error into account when calculating benchmark doses. Methods that allow this adjustment are described and illustrated in data from an epidemiological study on the health effects of prenatal mercury exposure.
U2 - 10.1111/j.0272-4332.2004.00560.x
DO - 10.1111/j.0272-4332.2004.00560.x
M3 - Journal article
C2 - 15660622
VL - 24
SP - 1689
EP - 1696
JO - Risk Analysis
JF - Risk Analysis
SN - 0272-4332
IS - 6
ER -
ID: 14359821