Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: A twelve-month randomized controlled trial
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Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients : A twelve-month randomized controlled trial. / Christensen, Robin; Henriksen, Marius; Leeds, Anthony R; Gudbergsen, Henrik; Christensen, Pia; Sørensen, Tina J; Bartels, Else Marie; Riecke, Birgit F; Aaboe, Jens; Frederiksen, Rikke; Boesen, Mikael; Lohmander, L Stefan; Astrup, Arne; Bliddal, Henning.
I: Arthritis Care & Research, Bind 67, Nr. 5, 2015, s. 640-650.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients
T2 - A twelve-month randomized controlled trial
AU - Christensen, Robin
AU - Henriksen, Marius
AU - Leeds, Anthony R
AU - Gudbergsen, Henrik
AU - Christensen, Pia
AU - Sørensen, Tina J
AU - Bartels, Else Marie
AU - Riecke, Birgit F
AU - Aaboe, Jens
AU - Frederiksen, Rikke
AU - Boesen, Mikael
AU - Lohmander, L Stefan
AU - Astrup, Arne
AU - Bliddal, Henning
N1 - CURIS 2015 NEXS 181
PY - 2015
Y1 - 2015
N2 - Objective To compare results of obese patients with knee osteoarthritis (OA) who, after an intensive weight loss regimen, received 1 year of either Dietary support (D), knee-Exercise program (E), or Control (C) "no attention". Methods Randomized, two-phase, parallel-group trial. 192 obese participants with knee OA were enrolled; mean age 62.5 y, 81% women with a mean entry weight of 103.2 kg. In phase-1, all participants were randomly assigned to one of three groups and began a dietary regimen of 400-810 and 1250 kcal/d for 8+8 weeks to achieve a major weight loss. Phase-2: 52 weeks maintenance in one of three groups D, E, or C. Outcomes: Changes from randomization in pain on a 100 mm Visual Analogue Scale, weight, and response according to OMERACT-OARSI criteria. Results Phase-1 mean weight loss was 12.8 kg. After 1 year on maintenance therapy, the D group sustained a lower weight (11.0 [95% CI: 9.0;12.8] kg) than those in the E (6.2 [4.4;8.1] kg), and C (8.2 [6.4;10.1] kg) groups (ANCOVA: P=.002). Adherence was low in the E group. All groups had statistically significant pain reduction (D: 6.1; E: 5.6; C: 5.5 mm) with no difference between groups (ANCOVA: P=.98). In each group 32 (50%), 26 (41%), and 33 (52%) participants responded to treatment, in D, E, and C groups, respectively; with no statistically significant difference in the number of responders (P=.41). Conclusion A significant weight reduction with a 1-year maintenance program improves knee OA symptoms irrespective of maintenance program. © 2014 American College of Rheumatology.
AB - Objective To compare results of obese patients with knee osteoarthritis (OA) who, after an intensive weight loss regimen, received 1 year of either Dietary support (D), knee-Exercise program (E), or Control (C) "no attention". Methods Randomized, two-phase, parallel-group trial. 192 obese participants with knee OA were enrolled; mean age 62.5 y, 81% women with a mean entry weight of 103.2 kg. In phase-1, all participants were randomly assigned to one of three groups and began a dietary regimen of 400-810 and 1250 kcal/d for 8+8 weeks to achieve a major weight loss. Phase-2: 52 weeks maintenance in one of three groups D, E, or C. Outcomes: Changes from randomization in pain on a 100 mm Visual Analogue Scale, weight, and response according to OMERACT-OARSI criteria. Results Phase-1 mean weight loss was 12.8 kg. After 1 year on maintenance therapy, the D group sustained a lower weight (11.0 [95% CI: 9.0;12.8] kg) than those in the E (6.2 [4.4;8.1] kg), and C (8.2 [6.4;10.1] kg) groups (ANCOVA: P=.002). Adherence was low in the E group. All groups had statistically significant pain reduction (D: 6.1; E: 5.6; C: 5.5 mm) with no difference between groups (ANCOVA: P=.98). In each group 32 (50%), 26 (41%), and 33 (52%) participants responded to treatment, in D, E, and C groups, respectively; with no statistically significant difference in the number of responders (P=.41). Conclusion A significant weight reduction with a 1-year maintenance program improves knee OA symptoms irrespective of maintenance program. © 2014 American College of Rheumatology.
U2 - 10.1002/acr.22504
DO - 10.1002/acr.22504
M3 - Journal article
C2 - 25370359
VL - 67
SP - 640
EP - 650
JO - Arthritis Care & Research
JF - Arthritis Care & Research
SN - 2151-464X
IS - 5
ER -
ID: 130285581