Effect of skull type on the relative size of cerebral cortex and lateral ventricles in dogs
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Effect of skull type on the relative size of cerebral cortex and lateral ventricles in dogs. / Pilegaard, Anders M.; Berendt, Mette; Holst, Pernille; Møller, Arne; McEvoy, Fintan J.
I: Frontiers in Veterinary Science, Bind 4, 30, 2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of skull type on the relative size of cerebral cortex and lateral ventricles in dogs
AU - Pilegaard, Anders M.
AU - Berendt, Mette
AU - Holst, Pernille
AU - Møller, Arne
AU - McEvoy, Fintan J.
PY - 2017
Y1 - 2017
N2 - Volume measurements of the brain are of interest in the diagnosis of brain pathology. This is particularly so in the investigation hydrocephalus and canine cognitive dysfunction (CCD), both of which result in thinning of the cerebral cortex and enlarged ventricles. Volume assessment can be made using computed tomography or more usually magnetic resonance imaging (MRI). There is, however, some uncertainty in the interpretation of such volume data due to the great variation in skull size and shape seen in dog. In this retrospective study, we examined normal MRI images from 63 dogs < 6 years of age. We used a continuous variable, the cranial index (CrI) to indicate skull shape and compared it with MRI volume measurements derived using Cavalieri's principle. We found a negative correlation between CrI and the ratio of cortical to ventricular volume. Breeds with a high CrI (large laterolateral compared to rostrocaudal cranial cavity dimension) had a smaller ratio of cortical to ventricular volume (low C:V ratio) than breeds with lower CrI skull types. It is important to consider this effect of skull shape on the relative volume estimates of the cerebral cortex and ventricles when trying to establish if pathology is present.
AB - Volume measurements of the brain are of interest in the diagnosis of brain pathology. This is particularly so in the investigation hydrocephalus and canine cognitive dysfunction (CCD), both of which result in thinning of the cerebral cortex and enlarged ventricles. Volume assessment can be made using computed tomography or more usually magnetic resonance imaging (MRI). There is, however, some uncertainty in the interpretation of such volume data due to the great variation in skull size and shape seen in dog. In this retrospective study, we examined normal MRI images from 63 dogs < 6 years of age. We used a continuous variable, the cranial index (CrI) to indicate skull shape and compared it with MRI volume measurements derived using Cavalieri's principle. We found a negative correlation between CrI and the ratio of cortical to ventricular volume. Breeds with a high CrI (large laterolateral compared to rostrocaudal cranial cavity dimension) had a smaller ratio of cortical to ventricular volume (low C:V ratio) than breeds with lower CrI skull types. It is important to consider this effect of skull shape on the relative volume estimates of the cerebral cortex and ventricles when trying to establish if pathology is present.
KW - Canine cognitive dysfunction
KW - Cavalieri's principle
KW - Cerebrum
KW - Hydrocephalus
KW - Lateral ventricles
KW - Skull type
U2 - 10.3389/fvets.2017.00030
DO - 10.3389/fvets.2017.00030
M3 - Journal article
C2 - 28361057
AN - SCOPUS:85038836426
VL - 4
JO - Frontiers in Veterinary Science
JF - Frontiers in Veterinary Science
SN - 2297-1769
M1 - 30
ER -
ID: 188369138