Effect of praziquantel treatment during pregnancy on cytokine responses to schistosome antigens: results of a randomized, placebo-controlled trial
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Effect of praziquantel treatment during pregnancy on cytokine responses to schistosome antigens : results of a randomized, placebo-controlled trial. / Tweyongyere, Robert; Mawa, Patrice A.; Ngom-Wegi, Sophy; Ndibazza, Juliet; Duong, Trinh; Vennervald, Birgitte J; Dunne, David W.; Katunguka-Rwakishaya, Eli; Elliott, Alison M.
I: Journal of Infectious Diseases, Bind 198, Nr. 12, 2008, s. 1870-1879.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Effect of praziquantel treatment during pregnancy on cytokine responses to schistosome antigens
T2 - results of a randomized, placebo-controlled trial
AU - Tweyongyere, Robert
AU - Mawa, Patrice A.
AU - Ngom-Wegi, Sophy
AU - Ndibazza, Juliet
AU - Duong, Trinh
AU - Vennervald, Birgitte J
AU - Dunne, David W.
AU - Katunguka-Rwakishaya, Eli
AU - Elliott, Alison M.
PY - 2008
Y1 - 2008
N2 - Praziquantel treatment of schistosomiasis boosts antischistosomeresponses, with type 2 helper T cell bias that may contribute to immunologically mediated killing and to protection against reinfection. Praziquantel treatmentduring pregnancy was recommended in 2002, but the immunological effects of thetreatment had not been investigated. METHODS: A cohort of 387 Schistosomamansoni-infected women were recruited from a larger trial of deworming duringpregnancy. Women were randomized to receive either praziquantel or placebo duringpregnancy. Six weeks after delivery, all women received praziquantel. Cytokineresponses to S. mansoni worm and egg antigens were measured in whole bloodculture before and 6 weeks after each treatment. RESULTS: Schistosome-specificcytokine responses were suppressed during pregnancy. Praziquantel treatmentduring pregnancy caused significant boosts in interferon-gamma (IFN-gamma),interleukin (IL)-2, IL-4, IL-5, IL-13, and IL-10 responses to schistosome wormantigen and in IFN-gamma, IL-5, and IL-13 responses to schistosome egg antigen,but these boosts were not as substantial as those seen for women treated afterdelivery. CONCLUSION: Pregnancy suppresses a potentially beneficial boost incytokine responses associated with praziquantel treatment. Further studies areneeded on the long-term effects that treatment of schistosomiasis duringpregnancy have on morbidity and resistance to reinfection among treated women andtheir offspring.
AB - Praziquantel treatment of schistosomiasis boosts antischistosomeresponses, with type 2 helper T cell bias that may contribute to immunologically mediated killing and to protection against reinfection. Praziquantel treatmentduring pregnancy was recommended in 2002, but the immunological effects of thetreatment had not been investigated. METHODS: A cohort of 387 Schistosomamansoni-infected women were recruited from a larger trial of deworming duringpregnancy. Women were randomized to receive either praziquantel or placebo duringpregnancy. Six weeks after delivery, all women received praziquantel. Cytokineresponses to S. mansoni worm and egg antigens were measured in whole bloodculture before and 6 weeks after each treatment. RESULTS: Schistosome-specificcytokine responses were suppressed during pregnancy. Praziquantel treatmentduring pregnancy caused significant boosts in interferon-gamma (IFN-gamma),interleukin (IL)-2, IL-4, IL-5, IL-13, and IL-10 responses to schistosome wormantigen and in IFN-gamma, IL-5, and IL-13 responses to schistosome egg antigen,but these boosts were not as substantial as those seen for women treated afterdelivery. CONCLUSION: Pregnancy suppresses a potentially beneficial boost incytokine responses associated with praziquantel treatment. Further studies areneeded on the long-term effects that treatment of schistosomiasis duringpregnancy have on morbidity and resistance to reinfection among treated women andtheir offspring.
U2 - 10.1086/593215
DO - 10.1086/593215
M3 - Journal article
C2 - 18983246
VL - 198
SP - 1870
EP - 1879
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 12
ER -
ID: 9449823