Effect of exercise on serum neutrophil gelatinase-associated lipocalin concentration in racehorses
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Effect of exercise on serum neutrophil gelatinase-associated lipocalin concentration in racehorses. / Flick, Marnie; Vinther, Anne M.L.; Jacobsen, Stine; Berg, Lise C.; Gimeno, Marina; Verwilghen, Denis; Howden, Wade; Averay, Kate; van Galen, Gaby.
I: Veterinary Clinical Pathology, Bind 50, Nr. 4, 2021, s. 551-554.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of exercise on serum neutrophil gelatinase-associated lipocalin concentration in racehorses
AU - Flick, Marnie
AU - Vinther, Anne M.L.
AU - Jacobsen, Stine
AU - Berg, Lise C.
AU - Gimeno, Marina
AU - Verwilghen, Denis
AU - Howden, Wade
AU - Averay, Kate
AU - van Galen, Gaby
N1 - Funding Information: We owe thanks to Kathy Brammall for her help in conducting the creatinine analysis. Also, the trainer of the racehorses, Richard Litt, is gratefully acknowledged for allowing us to sample his horses. Publisher Copyright: © 2021 American Society for Veterinary Clinical Pathology
PY - 2021
Y1 - 2021
N2 - Serum neutrophil gelatinase-associated lipocalin (sNGAL) is a marker of renal injury, and its concentrations are affected by inflammation. Therefore, it could serve as a useful biomarker of disease or fitness in high-level competition. However, it has not yet been determined if sNGAL concentrations are affected by exercise. The aim of this study was to determine whether concentrations of equine sNGAL were affected by 1000 m galloping as the form of exercise used in the study. Pre- and post-gallop sNGAL, serum amyloid A, and creatinine concentrations were evaluated in 14 healthy Thoroughbred racehorses. The results showed that short, high-intensity exercise did not significantly affect sNGAL concentrations in healthy horses (P =.42), and no significant difference was found in either creatinine or serum amyloid A before and after galloping (P >.05). Therefore, it was determined that sNGAL was not influenced by the type of exercise used in the study and could have the potential to be used as a routine laboratory screening tool in horses even after strenuous exercise. Future research should clarify its use in a larger population and a broader range of equine sport disciplines, including endurance-related exercise.
AB - Serum neutrophil gelatinase-associated lipocalin (sNGAL) is a marker of renal injury, and its concentrations are affected by inflammation. Therefore, it could serve as a useful biomarker of disease or fitness in high-level competition. However, it has not yet been determined if sNGAL concentrations are affected by exercise. The aim of this study was to determine whether concentrations of equine sNGAL were affected by 1000 m galloping as the form of exercise used in the study. Pre- and post-gallop sNGAL, serum amyloid A, and creatinine concentrations were evaluated in 14 healthy Thoroughbred racehorses. The results showed that short, high-intensity exercise did not significantly affect sNGAL concentrations in healthy horses (P =.42), and no significant difference was found in either creatinine or serum amyloid A before and after galloping (P >.05). Therefore, it was determined that sNGAL was not influenced by the type of exercise used in the study and could have the potential to be used as a routine laboratory screening tool in horses even after strenuous exercise. Future research should clarify its use in a larger population and a broader range of equine sport disciplines, including endurance-related exercise.
U2 - 10.1111/vcp.13027
DO - 10.1111/vcp.13027
M3 - Journal article
C2 - 34779025
AN - SCOPUS:85119247636
VL - 50
SP - 551
EP - 554
JO - Veterinary Clinical Pathology
JF - Veterinary Clinical Pathology
SN - 0275-6382
IS - 4
ER -
ID: 301353230