Effect of a nitric oxide donor (glyceryl trinitrate) on nociceptive thresholds in man
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Effect of a nitric oxide donor (glyceryl trinitrate) on nociceptive thresholds in man. / Thomsen, L L; Brennum, J; Iversen, Helle Klingenberg; Olesen, J.
I: Cephalalgia : an international journal of headache, Bind 16, Nr. 3, 05.1996, s. 169-74.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of a nitric oxide donor (glyceryl trinitrate) on nociceptive thresholds in man
AU - Thomsen, L L
AU - Brennum, J
AU - Iversen, Helle Klingenberg
AU - Olesen, J
PY - 1996/5
Y1 - 1996/5
N2 - Several animal studies suggest that nitric oxide (NO) plays a role in central and peripheral modulation of nociception. Glyceryl trinitrate (GTN) exerts its physiological actions via donation of NO. The purpose of the present study was to examine the effect of this NO donor on nociceptive thresholds in man. On two different study days separated by at least a week 12 healthy subjects received a staircase infusion of GTN (0.015, 0.25, 1.0, 2.0 micrograms/kg/min, 20 min each dose) or placebo in a randomized double-blind crossover design. Before the infusion and after 15 min of infusion on each dose, pressure pain detection and tolerance thresholds were determined by pressure algometry (Somomedic AB, Sweden) in three different anatomic regions (finger, a temporal region with interposed myofascial tissue and a temporal region without interposed myofascial tissue). Relative to placebo, the three higher GTN doses induced a decrease in both detection and tolerance thresholds in the temporal region with interposed myofascial tissue (p = 0.003 detection and p = 0.002 tolerance thresholds, Friedman). No such changes were observed in the other two stimulated regions. These results could reflect central facilitation of nociception by NO. However, we regard convergence of nociceptive input from pericranial myofascial tissue and from cephalic blood vessels dilated by NO as a more likely explanation of our findings.
AB - Several animal studies suggest that nitric oxide (NO) plays a role in central and peripheral modulation of nociception. Glyceryl trinitrate (GTN) exerts its physiological actions via donation of NO. The purpose of the present study was to examine the effect of this NO donor on nociceptive thresholds in man. On two different study days separated by at least a week 12 healthy subjects received a staircase infusion of GTN (0.015, 0.25, 1.0, 2.0 micrograms/kg/min, 20 min each dose) or placebo in a randomized double-blind crossover design. Before the infusion and after 15 min of infusion on each dose, pressure pain detection and tolerance thresholds were determined by pressure algometry (Somomedic AB, Sweden) in three different anatomic regions (finger, a temporal region with interposed myofascial tissue and a temporal region without interposed myofascial tissue). Relative to placebo, the three higher GTN doses induced a decrease in both detection and tolerance thresholds in the temporal region with interposed myofascial tissue (p = 0.003 detection and p = 0.002 tolerance thresholds, Friedman). No such changes were observed in the other two stimulated regions. These results could reflect central facilitation of nociception by NO. However, we regard convergence of nociceptive input from pericranial myofascial tissue and from cephalic blood vessels dilated by NO as a more likely explanation of our findings.
KW - Adult
KW - Cross-Over Studies
KW - Double-Blind Method
KW - Female
KW - Headache
KW - Hemodynamics
KW - Humans
KW - Male
KW - Nitric Oxide
KW - Nitroglycerin
KW - Pain Threshold
KW - Stress, Mechanical
M3 - Journal article
C2 - 8734768
VL - 16
SP - 169
EP - 174
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 3
ER -
ID: 128983998