Effect of a common variant of the PCSK2 gene on reduced insulin secretion
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.
Originalsprog | Engelsk |
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Tidsskrift | Diabetologia |
Vol/bind | 55 |
Udgave nummer | 12 |
Sider (fra-til) | 3245-51 |
Antal sider | 7 |
ISSN | 0012-186X |
DOI | |
Status | Udgivet - dec. 2012 |
ID: 46403756