EEG recording latency in critically ill patients: Impact on outcome. An analysis of a randomized controlled trial (CERTA)
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Objective: To assess, in adults with acute consciousness impairment, the impact of latency between hospital admission and EEG recording start, and their outcome. Methods: We reviewed data of the CERTA trial (NCT03129438) and explored correlations between EEG recording latency and mortality, Cerebral Performance Categories (CPC), and modified Rankin Scale (mRS) at 6 months, considering other variables, using uni- and multivariable analyses. Results: In univariable analysis of 364 adults, median latency between admission and EEG recordings was comparable between surviving (61.1 h; IQR: 24.3–137.7) and deceased patients (57.5 h; IQR: 22.3–141.1); p = 0.727. This did not change after adjusting for potential confounders, such as lower Glasgow Coma Score on enrolment (p < 0.001) and seizure or status epilepticus detection (p < 0.001). There was neither any correlation between EEG latency and mRS (rho 0.087, p 0.236), nor with CPC (rho = 0.027, p = 0.603). Conclusion: This analysis shows no correlation between delays of EEG recordings and mortality or functional outcomes at 6 months in critically ill adults. Significance: These findings might suggest that in critically ill adults mortality correlates with underlying brain injury rather than EEG delay.
Originalsprog | Engelsk |
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Bogserie | Clinical Neurophysiology |
Vol/bind | 139 |
Sider (fra-til) | 23-27 |
Antal sider | 5 |
ISSN | 1388-2457 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
The authors thank Vassili Soumas for assistance in data extraction and the Swiss National Science Foundation for financial support.
Funding Information:
The Swiss National Science Foundation (grant 320030_169379) supported this work and it played no role in any of the aspects of the study.
Publisher Copyright:
© 2022 International Federation of Clinical Neurophysiology
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