Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke
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Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. / Zangari, Rosalia; Zanier, Elisa R; Torgano, G; Bersano, A; Beretta, S; Beghi, Ettore; Casolla, B; Checcarelli, N; Lanfranconi, S; Maino, A; Mandelli, C; Micieli, G; Orzi, F; Picetti, E; Silvestrini, M; Stocchetti, Nino; Zecca, B; Garred, P; De Simoni, Maria-Grazia; LEPAS group.
I: Journal of Neuroinflammation, Bind 13, 16, 2016.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke
AU - Zangari, Rosalia
AU - Zanier, Elisa R
AU - Torgano, G
AU - Bersano, A
AU - Beretta, S
AU - Beghi, Ettore
AU - Casolla, B
AU - Checcarelli, N
AU - Lanfranconi, S
AU - Maino, A
AU - Mandelli, C
AU - Micieli, G
AU - Orzi, F
AU - Picetti, E
AU - Silvestrini, M
AU - Stocchetti, Nino
AU - Zecca, B
AU - Garred, P
AU - De Simoni, Maria-Grazia
AU - LEPAS group
PY - 2016
Y1 - 2016
N2 - BACKGROUND: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke.METHODS: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS).RESULTS: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p < 0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p < 0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p < 0.001 and <0.05, respectively). For MBL no difference was detected between patients and controls or within patients at the different time points. In multivariate analysis, early ficolin-1 was independently associated with unfavorable mRS outcome (adjusted odds ratio (OR): 2.21, confidence interval (CI) 95 % 1.11-4.39, p = 0.023). Early ficolin-1 improved the discriminating ability of an outcome model including NIHSS and age (area under the curve (AUC) 0.95, CI 95 % 0.90-0.99, p = 0.0001).CONCLUSIONS: The ficolins are consumed within 6 h after stroke implicating activation of the LP. Early ficolin-1 is selectively related to 3-month unfavorable outcome.
AB - BACKGROUND: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke.METHODS: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS).RESULTS: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p < 0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p < 0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p < 0.001 and <0.05, respectively). For MBL no difference was detected between patients and controls or within patients at the different time points. In multivariate analysis, early ficolin-1 was independently associated with unfavorable mRS outcome (adjusted odds ratio (OR): 2.21, confidence interval (CI) 95 % 1.11-4.39, p = 0.023). Early ficolin-1 improved the discriminating ability of an outcome model including NIHSS and age (area under the curve (AUC) 0.95, CI 95 % 0.90-0.99, p = 0.0001).CONCLUSIONS: The ficolins are consumed within 6 h after stroke implicating activation of the LP. Early ficolin-1 is selectively related to 3-month unfavorable outcome.
KW - Adult
KW - Age Factors
KW - Aged
KW - Brain Ischemia
KW - Case-Control Studies
KW - Cohort Studies
KW - Female
KW - Humans
KW - Italy
KW - Lectins
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Regression Analysis
KW - Risk Factors
KW - Severity of Illness Index
KW - Statistics, Nonparametric
KW - Stroke
KW - Time Factors
KW - Journal Article
KW - Multicenter Study
KW - Research Support, Non-U.S. Gov't
U2 - 10.1186/s12974-016-0481-2
DO - 10.1186/s12974-016-0481-2
M3 - Journal article
C2 - 26792363
VL - 13
JO - Journal of Neuroinflammation
JF - Journal of Neuroinflammation
SN - 1742-2094
M1 - 16
ER -
ID: 176993135