Early environmental risk factors and coeliac disease in adolescents: A population-based cohort study in Denmark
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Design The study was designed as a prospective cohort study, nested in DNBC
Participants The Glutenfunen cohort comprises 1266 participants, nested in DNBC. All participants were screened for CeD, and in total, 28 cases of biopsy proven CeD were identified. Data about breastfeeding, timing of introduction to solid food in infancy, use of antibiotics, infections and symptoms were parentally reported prospectively at 6 months and 18 months, respectively. We estimated ORs and 95% CIs of CeD in adolescents using logistic regression analysis.
Results Viral croup reported at 18 months of age was associated with CeD in adolescents with an OR of 3.2 (95% CI: 1.2 to 8.7). Furthermore, otitis media also reported at 18 months of age was linked with CeD with an OR of 3.2 (95% CI: 1.5 to 7.3). We were not able to find any statistical associations between CeD and breastfeeding, frequency of infections, parentally reported use of antibiotic and timing of solid foods.
Conclusion In this study, we present an overview of the relationship between early environmental factors and occurrence of CeD in adolescents. Our findings, despite limitations due to a limited number of cases of CeD, suggest a role of viral infections in the pathogenesis of CeD
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | e061006 |
| Tidsskrift | BMJ Open |
| Vol/bind | 13 |
| Udgave nummer | 11 |
| Antal sider | 8 |
| ISSN | 2044-6055 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The authors would like to thank the Danish National Birth Cohort (DNBC) participants, especially those who entered the Glutenfunen cohort. The DNBC was established with a significant grant from the Danish National Research Foundation. Additional support was obtained from the Danish Regional Committees, the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Health Foundation and other minor grants. The DNBC Biobank has been supported by the Novo Nordisk Foundation and the Lundbeck Foundation. Follow-up of mothers and children have been supported by the Danish Medical Research Council (SSVF 0646, 271-08-0839/06-066023, O602-01042B, 0602-02738B), the Lundbeck Foundation (195/04, R100-A9193), The Innovation Fund Denmark 0603-00294B (09-067124), the Nordea Foundation (02-2013-2014), Aarhus Ideas (AU R9-A959-13-S804), University of Copenhagen Strategic Grant (IFSV 2012) and the Danish Council for Independent Research (DFF-4183-00594 and DFF-4183-00152).
Funding Information:
This work was supported by the AP Møller Fund (19-L-0228 and 18-L-0032), Odense University Hospital Research Fund (A3675 and A 2971), Direktør Kurt Bønnelyckes og hustru Fru Grethe Bønnelyckes Fund (100 53030), Torben og Alice Frimodts Fund (n/a) and LF Foghts Fund (21.844) to CC and the Augustinus Fund (19-2419) to SH. Thermo Fischer (n/a) donated 70.000 $, they had no influence on the design of the study. CC holds a Ph.D. funded by University of Southern Denmark, The Region of Southern Denmark and Hans Christian Anderson Children’s Hospital. Department of Clinical Immunology, Odense University Hospital hold the cost of the analyses of the coeliac screening.
Publisher Copyright:
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
ID: 396091887