Early environmental risk factors and coeliac disease in adolescents: A population-based cohort study in Denmark
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Early environmental risk factors and coeliac disease in adolescents : A population-based cohort study in Denmark. / Crawley, Cæcilie; Sander, Stine Dydensborg; Nohr, Ellen Aagaard; Nybo Andersen, Anne Marie; Husby, Steffen.
I: BMJ Open, Bind 13, Nr. 11, e061006, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Early environmental risk factors and coeliac disease in adolescents
T2 - A population-based cohort study in Denmark
AU - Crawley, Cæcilie
AU - Sander, Stine Dydensborg
AU - Nohr, Ellen Aagaard
AU - Nybo Andersen, Anne Marie
AU - Husby, Steffen
N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023
Y1 - 2023
N2 - Objectives Our aim was to investigate the association between early environmental factors and the development of coeliac disease (CeD) in adolescents, recruited from a cohort nested in the Danish National Birth Cohort (DNBC). Design The study was designed as a prospective cohort study, nested in DNBC Participants The Glutenfunen cohort comprises 1266 participants, nested in DNBC. All participants were screened for CeD, and in total, 28 cases of biopsy proven CeD were identified. Data about breastfeeding, timing of introduction to solid food in infancy, use of antibiotics, infections and symptoms were parentally reported prospectively at 6 months and 18 months, respectively. We estimated ORs and 95% CIs of CeD in adolescents using logistic regression analysis. Results Viral croup reported at 18 months of age was associated with CeD in adolescents with an OR of 3.2 (95% CI: 1.2 to 8.7). Furthermore, otitis media also reported at 18 months of age was linked with CeD with an OR of 3.2 (95% CI: 1.5 to 7.3). We were not able to find any statistical associations between CeD and breastfeeding, frequency of infections, parentally reported use of antibiotic and timing of solid foods. Conclusion In this study, we present an overview of the relationship between early environmental factors and occurrence of CeD in adolescents. Our findings, despite limitations due to a limited number of cases of CeD, suggest a role of viral infections in the pathogenesis of CeD
AB - Objectives Our aim was to investigate the association between early environmental factors and the development of coeliac disease (CeD) in adolescents, recruited from a cohort nested in the Danish National Birth Cohort (DNBC). Design The study was designed as a prospective cohort study, nested in DNBC Participants The Glutenfunen cohort comprises 1266 participants, nested in DNBC. All participants were screened for CeD, and in total, 28 cases of biopsy proven CeD were identified. Data about breastfeeding, timing of introduction to solid food in infancy, use of antibiotics, infections and symptoms were parentally reported prospectively at 6 months and 18 months, respectively. We estimated ORs and 95% CIs of CeD in adolescents using logistic regression analysis. Results Viral croup reported at 18 months of age was associated with CeD in adolescents with an OR of 3.2 (95% CI: 1.2 to 8.7). Furthermore, otitis media also reported at 18 months of age was linked with CeD with an OR of 3.2 (95% CI: 1.5 to 7.3). We were not able to find any statistical associations between CeD and breastfeeding, frequency of infections, parentally reported use of antibiotic and timing of solid foods. Conclusion In this study, we present an overview of the relationship between early environmental factors and occurrence of CeD in adolescents. Our findings, despite limitations due to a limited number of cases of CeD, suggest a role of viral infections in the pathogenesis of CeD
KW - coeliac disease
KW - epidemiology
KW - paediatric gastroenterology
U2 - 10.1136/bmjopen-2022-061006
DO - 10.1136/bmjopen-2022-061006
M3 - Journal article
C2 - 38011980
AN - SCOPUS:85178499360
VL - 13
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 11
M1 - e061006
ER -
ID: 396091887