TY - JOUR

T1 - EAACI Molecular Allergology User's Guide 2.0

AU - Dramburg, Stephanie

AU - Hilger, Christiane

AU - Santos, Alexandra F.

AU - de las Vecillas, Leticia

AU - Aalberse, Rob C.

AU - Acevedo, Nathalie

AU - Aglas, Lorenz

AU - Altmann, Friedrich

AU - Arruda, Karla L.

AU - Asero, Riccardo

AU - Ballmer-Weber, Barbara

AU - Barber, Domingo

AU - Beyer, Kirsten

AU - Biedermann, Tilo

AU - Bilo, Maria Beatrice

AU - Blank, Simon

AU - Bosshard, Philipp P

AU - Breiteneder, Heimo

AU - Brough, Helen A.

AU - Bublin, Merima

AU - Campbell, Dianne

AU - Caraballo, Luis

AU - Caubet, Jean Christoph

AU - Celi, Giorgio

AU - Chapman, Martin D.

AU - Chruszcz, Maksymilian

AU - Custovic, Adnan

AU - Czolk, Rebecca

AU - Davies, Janet

AU - Douladiris, Nikolaos

AU - Eberlein, Bernadette

AU - Ebisawa, Motohiro

AU - Ehlers, Anna

AU - Eigenmann, Philippe

AU - Gadermaier, Gabriele

AU - Giovannini, Mattia

AU - Gomez, Francisca

AU - Grohman, Rebecca

AU - Guillet, Carole

AU - Hafner, Christine

AU - Hamilton, Robert G

AU - Hauser, Michael

AU - Hawranek, Thomas

AU - Hoffmann, Hans Jürgen

AU - Holzhauser, Thomas

AU - Iizuka, Tomona

AU - Jacquet, Alain

AU - Jakob, Thilo

AU - Janssen-Weets, Bente

AU - Jappe, Uta

AU - Jutel, Marek

AU - Kalic, Tanja

AU - Kamath, Sandip

AU - Kespohl, Sabine

AU - Kleine-Tebbe, Jörg

AU - Knol, Edward

AU - Knulst, André

AU - Konradsen, Jon R.

AU - Korošec, Peter

AU - Kuehn, Annette

AU - Lack, Gideon

AU - Le, Thuy My

AU - Lopata, Andreas

AU - Luengo, Olga

AU - Mäkelä, Mika

AU - Marra, Alessandro Maria

AU - Mills, Clare

AU - Morisset, Martine

AU - Muraro, Antonella

AU - Nowak-Wegrzyn, Anna

AU - Nugraha, Roni

AU - Ollert, Markus

AU - Palosuo, Kati

AU - Pastorello, Elide Anna

AU - Patil, Sarita Ulhas

AU - Platts-Mills, Thomas

AU - Pomés, Anna

AU - Poncet, Pascal

AU - Potapova, Ekaterina

AU - Poulsen, Lars K.

AU - Radauer, Christian

AU - Radulovic, Suzana

AU - Raulf, Monika

AU - Rougé, Pierre

AU - Sastre, Joaquin

AU - Sato, Sakura

AU - Scala, Enrico

AU - Schmid, Johannes M.

AU - Schmid-Grendelmeier, Peter

AU - Schrama, Denise

AU - Sénéchal, Hélène

AU - Traidl-Hoffmann, Claudia

AU - Valverde-Monge, Marcela

AU - van Hage, Marianne

AU - van Ree, Ronald

AU - Verhoeckx, Kitty

AU - Vieths, Stefan

AU - Wickman, Magnus

AU - Zakzuk, Josefina

AU - Matricardi, Paolo M

AU - Hoffmann-Sommergruber, Karin

N1 - Publisher Copyright: © 2023 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

PY - 2023

Y1 - 2023

N2 - Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

AB - Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

KW - allergy

KW - allergy diagnosis

KW - anaphylaxis

KW - asthma

KW - atopic dermatitis

KW - basophil activation test

KW - component-resolved diagnosis

KW - cross-reactive carbohydrates

KW - diagnostic algorithms

KW - food allergy

KW - gibberellin-regulated proteins

KW - IgE

KW - IgE cross-reactivity

KW - lipocalins

KW - microarray

KW - molecular allergology

KW - non-specific lipid transfer proteins

KW - oleosins

KW - pan-allergens

KW - parvalbumins

KW - pathogenesis-related protein family 10

KW - polcalcins

KW - pollen allergy

KW - precision medicine

KW - profilins

KW - seed storage proteins

KW - serum albumins

KW - tropomyosins

U2 - 10.1111/pai.13854

DO - 10.1111/pai.13854

M3 - Journal article

C2 - 37186333

AN - SCOPUS:85153787295

VL - 34

JO - Pediatric Allergy and Immunology, Supplement

JF - Pediatric Allergy and Immunology, Supplement

SN - 0906-5784

IS - S28

M1 - e13854

ER -