E2F transcription regulation: an orphan cyclin enters the stage
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E2F transcription regulation : an orphan cyclin enters the stage. / Rösner, Heike Ilona; Sørensen, Claus Storgaard.
I: The EMBO Journal, Bind 38, Nr. 20, e103421, 2019.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - E2F transcription regulation
T2 - an orphan cyclin enters the stage
AU - Rösner, Heike Ilona
AU - Sørensen, Claus Storgaard
N1 - © 2019 The Authors.
PY - 2019
Y1 - 2019
N2 - Marked cyclin protein oscillations over the cell cycle ensure tight regulation of all cell cycle transitions. Despite expression patterns closely mirroring those of cyclin A, cyclin F has long been regarded as an odd outlier within the cyclin family. Constituting part of an E3 ubiquitin ligase, its main role was seen as highly restricted to timely degradation of very few key substrates to ensure termination of one error-free round of replication. Now, a recent series of studies suggests that cyclin F has very similar roles as its closest relatives, merely mediated through a very different mechanism.
AB - Marked cyclin protein oscillations over the cell cycle ensure tight regulation of all cell cycle transitions. Despite expression patterns closely mirroring those of cyclin A, cyclin F has long been regarded as an odd outlier within the cyclin family. Constituting part of an E3 ubiquitin ligase, its main role was seen as highly restricted to timely degradation of very few key substrates to ensure termination of one error-free round of replication. Now, a recent series of studies suggests that cyclin F has very similar roles as its closest relatives, merely mediated through a very different mechanism.
U2 - 10.15252/embj.2019103421
DO - 10.15252/embj.2019103421
M3 - Journal article
C2 - 31566762
VL - 38
JO - E M B O Journal
JF - E M B O Journal
SN - 0261-4189
IS - 20
M1 - e103421
ER -
ID: 228727060