Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers

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Standard

Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers. / Andreou, Dimitrios; Saetre, Peter; Kähler, Anna K; Werge, Thomas; Andreassen, Ole A; Agartz, Ingrid; Sedvall, Göran C; Hall, Håkan; Terenius, Lars; Jönsson, Erik G.

I: European Neuropsychopharmacology, Bind 21, Nr. 9, 09.2011, s. 700-4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Andreou, D, Saetre, P, Kähler, AK, Werge, T, Andreassen, OA, Agartz, I, Sedvall, GC, Hall, H, Terenius, L & Jönsson, EG 2011, 'Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers', European Neuropsychopharmacology, bind 21, nr. 9, s. 700-4. https://doi.org/10.1016/j.euroneuro.2010.12.008, https://doi.org/10.1016/j.euroneuro.2010.12.008

APA

Andreou, D., Saetre, P., Kähler, A. K., Werge, T., Andreassen, O. A., Agartz, I., Sedvall, G. C., Hall, H., Terenius, L., & Jönsson, E. G. (2011). Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers. European Neuropsychopharmacology, 21(9), 700-4. https://doi.org/10.1016/j.euroneuro.2010.12.008, https://doi.org/10.1016/j.euroneuro.2010.12.008

Vancouver

Andreou D, Saetre P, Kähler AK, Werge T, Andreassen OA, Agartz I o.a. Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers. European Neuropsychopharmacology. 2011 sep.;21(9):700-4. https://doi.org/10.1016/j.euroneuro.2010.12.008, https://doi.org/10.1016/j.euroneuro.2010.12.008

Author

Andreou, Dimitrios ; Saetre, Peter ; Kähler, Anna K ; Werge, Thomas ; Andreassen, Ole A ; Agartz, Ingrid ; Sedvall, Göran C ; Hall, Håkan ; Terenius, Lars ; Jönsson, Erik G. / Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers. I: European Neuropsychopharmacology. 2011 ; Bind 21, Nr. 9. s. 700-4.

Bibtex

@article{1137c9c3d30e4a139b2d6f5b5de69f60,
title = "Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers",
abstract = "The dystrobrevin binding protein-1 (DTNBP1) gene encodes dysbindin-1, a protein involved in neurodevelopmental and neurochemical processes related mainly to the monoamine dopamine. We investigated possible associations between eleven DTNBP1 polymorphisms and cerebrospinal fluid (CSF) concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy human subjects (n=132). Two polymorphisms, rs2619538 and rs760666, were nominally associated with CSF HVA and 5-HIAA concentrations, whereas a third polymorphism, rs909706, showed association only with HVA. After correction for multiple testing only the associations between rs2619538 and HVA and 5-HIAA concentrations remained significant. No significant association was found between any of the investigated DTNBP1 polymorphisms and CSF MHPG concentrations. The results suggest that genetic variation in DTNBP1 gene affects the regulation of dopamine and serotonin turnover in the central nervous system of healthy volunteers.",
author = "Dimitrios Andreou and Peter Saetre and K{\"a}hler, {Anna K} and Thomas Werge and Andreassen, {Ole A} and Ingrid Agartz and Sedvall, {G{\"o}ran C} and H{\aa}kan Hall and Lars Terenius and J{\"o}nsson, {Erik G}",
note = "Copyright {\textcopyright} 2011 Elsevier B.V. All rights reserved.",
year = "2011",
month = sep,
doi = "10.1016/j.euroneuro.2010.12.008",
language = "English",
volume = "21",
pages = "700--4",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers

AU - Andreou, Dimitrios

AU - Saetre, Peter

AU - Kähler, Anna K

AU - Werge, Thomas

AU - Andreassen, Ole A

AU - Agartz, Ingrid

AU - Sedvall, Göran C

AU - Hall, Håkan

AU - Terenius, Lars

AU - Jönsson, Erik G

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011/9

Y1 - 2011/9

N2 - The dystrobrevin binding protein-1 (DTNBP1) gene encodes dysbindin-1, a protein involved in neurodevelopmental and neurochemical processes related mainly to the monoamine dopamine. We investigated possible associations between eleven DTNBP1 polymorphisms and cerebrospinal fluid (CSF) concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy human subjects (n=132). Two polymorphisms, rs2619538 and rs760666, were nominally associated with CSF HVA and 5-HIAA concentrations, whereas a third polymorphism, rs909706, showed association only with HVA. After correction for multiple testing only the associations between rs2619538 and HVA and 5-HIAA concentrations remained significant. No significant association was found between any of the investigated DTNBP1 polymorphisms and CSF MHPG concentrations. The results suggest that genetic variation in DTNBP1 gene affects the regulation of dopamine and serotonin turnover in the central nervous system of healthy volunteers.

AB - The dystrobrevin binding protein-1 (DTNBP1) gene encodes dysbindin-1, a protein involved in neurodevelopmental and neurochemical processes related mainly to the monoamine dopamine. We investigated possible associations between eleven DTNBP1 polymorphisms and cerebrospinal fluid (CSF) concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy human subjects (n=132). Two polymorphisms, rs2619538 and rs760666, were nominally associated with CSF HVA and 5-HIAA concentrations, whereas a third polymorphism, rs909706, showed association only with HVA. After correction for multiple testing only the associations between rs2619538 and HVA and 5-HIAA concentrations remained significant. No significant association was found between any of the investigated DTNBP1 polymorphisms and CSF MHPG concentrations. The results suggest that genetic variation in DTNBP1 gene affects the regulation of dopamine and serotonin turnover in the central nervous system of healthy volunteers.

U2 - 10.1016/j.euroneuro.2010.12.008

DO - 10.1016/j.euroneuro.2010.12.008

M3 - Journal article

C2 - 21295953

VL - 21

SP - 700

EP - 704

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 9

ER -

ID: 34193695