Dual purpose use of preterm piglets as a model of pediatric GI disease
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Dual purpose use of preterm piglets as a model of pediatric GI disease. / Oosterloo, Berthe C; Premkumar, Muralidhar; Stoll, Barbara; Olutoye, Oluyinka; Thymann, Thomas; Sangild, Per Torp; Burrin, Douglas G.
I: Veterinary Immunology and Immunopathology, Bind 159, Nr. 3-4, 2014, s. 156-165.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Dual purpose use of preterm piglets as a model of pediatric GI disease
AU - Oosterloo, Berthe C
AU - Premkumar, Muralidhar
AU - Stoll, Barbara
AU - Olutoye, Oluyinka
AU - Thymann, Thomas
AU - Sangild, Per Torp
AU - Burrin, Douglas G
N1 - CURIS 2014 NEXS 127
PY - 2014
Y1 - 2014
N2 - Necrotizing enterocolitis (NEC) is the most common gastrointestinal complication in human neonates, yet the pathogenesis of this disease remains poorly understood. A fundamental approach to understanding the etiology and underlying biology of NEC is the use of in vivo experimental animal models, primarly neonatal rodents and pigs. The rodent models using rats and mice have provided a much of the experimental evidence showing the protective influence of breast milk and the role of specific molecular mechanisms involved in the premature innate immune and intestinal injury response. A key advantage of mice is the abilty to test how genetic disruption of specific genes alters the NEC phenotype. More recently, pigs have emerged as an animal model of NEC and used to establish the role of bacterial colonization, prematurity, parenteral nutrition and antibiotic therapy. This review will outline some of the advantages and disadvantages of both rodent and pig models and highlight the lessons learned about NEC pathobiology from these different experimental models.
AB - Necrotizing enterocolitis (NEC) is the most common gastrointestinal complication in human neonates, yet the pathogenesis of this disease remains poorly understood. A fundamental approach to understanding the etiology and underlying biology of NEC is the use of in vivo experimental animal models, primarly neonatal rodents and pigs. The rodent models using rats and mice have provided a much of the experimental evidence showing the protective influence of breast milk and the role of specific molecular mechanisms involved in the premature innate immune and intestinal injury response. A key advantage of mice is the abilty to test how genetic disruption of specific genes alters the NEC phenotype. More recently, pigs have emerged as an animal model of NEC and used to establish the role of bacterial colonization, prematurity, parenteral nutrition and antibiotic therapy. This review will outline some of the advantages and disadvantages of both rodent and pig models and highlight the lessons learned about NEC pathobiology from these different experimental models.
U2 - 10.1016/j.vetimm.2014.02.012
DO - 10.1016/j.vetimm.2014.02.012
M3 - Journal article
C2 - 24656979
VL - 159
SP - 156
EP - 165
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
SN - 0165-2427
IS - 3-4
ER -
ID: 109553085