Drug and gene electrotransfer in cancer therapy
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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Drug and gene electrotransfer in cancer therapy. / Gehl, Julie.
Somatic Genome Manipulation: Advances, Methods, and Applications. Springer New York, 2015. s. 3-15.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Drug and gene electrotransfer in cancer therapy
AU - Gehl, Julie
N1 - Publisher Copyright: © Springer Science+Business Media, LLC 2015.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Drug and gene delivery by electroporation is gaining increasing momentum, in particular delivery of chemotherapeutic agents (electrochemotherapy) is now routinely used in many cancer centers, and gene therapy is in clinical trials. Gene therapy using electrotransfer offers the possibility to create a localized area hosting the transgene, with possibility for (1) local effects on tumors, (2) systemic effect through local activation of the immune system, or (3) local production of the transgenic protein followed by secretion to the systemic circulation, where these drugs may exert desired effects on cancer cells, and/or on supportive structures such as blood vessels. An increasing amount of knowledge is accumulating on important pathways for cancer progression, and this allows discovery of new targets for cancer therapy. Gene therapy offers an easier and less expensive strategy for therapy, since DNA may be produced more easily than formulation of protein drugs, enabling a higher level of access to new potential drugs. Many cancer gene therapy clinical trials are ongoing at this time, and it will be very interesting to follow the clinical results. This chapter reviews the progress in drug and gene electrotransfer, describes the details of the procedure, as well as offers the perspectives for this technology.
AB - Drug and gene delivery by electroporation is gaining increasing momentum, in particular delivery of chemotherapeutic agents (electrochemotherapy) is now routinely used in many cancer centers, and gene therapy is in clinical trials. Gene therapy using electrotransfer offers the possibility to create a localized area hosting the transgene, with possibility for (1) local effects on tumors, (2) systemic effect through local activation of the immune system, or (3) local production of the transgenic protein followed by secretion to the systemic circulation, where these drugs may exert desired effects on cancer cells, and/or on supportive structures such as blood vessels. An increasing amount of knowledge is accumulating on important pathways for cancer progression, and this allows discovery of new targets for cancer therapy. Gene therapy offers an easier and less expensive strategy for therapy, since DNA may be produced more easily than formulation of protein drugs, enabling a higher level of access to new potential drugs. Many cancer gene therapy clinical trials are ongoing at this time, and it will be very interesting to follow the clinical results. This chapter reviews the progress in drug and gene electrotransfer, describes the details of the procedure, as well as offers the perspectives for this technology.
KW - Cancer
KW - DNA
KW - Electrochemotherapy
KW - Electroporation
KW - Gene electrotransfer
KW - Personalized medicine
KW - PNA
KW - Signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=84944552800&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-2389-2_1
DO - 10.1007/978-1-4939-2389-2_1
M3 - Book chapter
AN - SCOPUS:84944552800
SN - 9781493923885
SP - 3
EP - 15
BT - Somatic Genome Manipulation
PB - Springer New York
ER -
ID: 318950589