Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis
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Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis. / Troelsen, Lone N; Garred, Peter; Christiansen, Buris; Torp-Pedersen, Christian; Christensen, Ib J; Narvestad, Eva; Jacobsen, Søren; Troelsen, Lone N; Garred, Peter; Christiansen, Buris; Torp-Pedersen, Christian; Christensen, Ib J; Narvestad, Eva; Jacobsen, Søren.
I: Molecular Immunology, Bind 47, Nr. 4, 01.01.2010, s. 713-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis
AU - Troelsen, Lone N
AU - Garred, Peter
AU - Christiansen, Buris
AU - Torp-Pedersen, Christian
AU - Christensen, Ib J
AU - Narvestad, Eva
AU - Jacobsen, Søren
AU - Troelsen, Lone N
AU - Garred, Peter
AU - Christiansen, Buris
AU - Torp-Pedersen, Christian
AU - Christensen, Ib J
AU - Narvestad, Eva
AU - Jacobsen, Søren
N1 - Keywords: Adult; Aged; Arthritis, Rheumatoid; Cardiovascular Diseases; Carotid Artery, Common; Denmark; Female; Genotype; Humans; Linear Models; Male; Mannose-Binding Lectin; Middle Aged; Risk Factors; Statistics, Nonparametric; Tunica Intima; Tunica Media
PY - 2010/1/1
Y1 - 2010/1/1
N2 - BACKGROUND: Patients with rheumatoid arthritis (RA) have increased risk of atherosclerosis and cardiovascular disease (CVD) that cannot be explained by excess of traditional risk factors. Several studies indicate that mannose-binding lectin (MBL) may modify the development of atherosclerosis; both high and low serum levels of MBL are reported to be associated with CVD. Intima-media thickness of the common carotid artery (ccIMT) is a validated non-invasive anatomic measure of subclinical CVD. We examined the relation between ccIMT and MBL in 114 RA patients. METHODS: In a cross-sectional study MBL2 genotypes and serum concentrations of MBL were assessed; ccIMT was determined by means of ultrasonography; traditional and RA related cardiovascular risk modifiers were measured. RESULTS: The median ccIMT was 0.67 mm. The investigated MBL2 genotypes were not significantly associated with ccIMT. Using a general linear model, ccIMT was not linearly associated with serum MBL but was highly associated with the quadratic term of serum MBL (MBL(2)) (P=0.001) reflecting a U-shaped relation. MBL(2) was also significantly associated with ccIMT in a multivariable analysis adjusting for traditional and RA related cardiovascular risk modifiers (P=0.025). CONCLUSION: In RA patients, a quadratic U-shaped relation between serum MBL and ccIMT was observed independently of the effects of traditional and RA related risk factors for CVD. These results provide further support to the notion that both high and low levels of MBL may be associated with CVD.
AB - BACKGROUND: Patients with rheumatoid arthritis (RA) have increased risk of atherosclerosis and cardiovascular disease (CVD) that cannot be explained by excess of traditional risk factors. Several studies indicate that mannose-binding lectin (MBL) may modify the development of atherosclerosis; both high and low serum levels of MBL are reported to be associated with CVD. Intima-media thickness of the common carotid artery (ccIMT) is a validated non-invasive anatomic measure of subclinical CVD. We examined the relation between ccIMT and MBL in 114 RA patients. METHODS: In a cross-sectional study MBL2 genotypes and serum concentrations of MBL were assessed; ccIMT was determined by means of ultrasonography; traditional and RA related cardiovascular risk modifiers were measured. RESULTS: The median ccIMT was 0.67 mm. The investigated MBL2 genotypes were not significantly associated with ccIMT. Using a general linear model, ccIMT was not linearly associated with serum MBL but was highly associated with the quadratic term of serum MBL (MBL(2)) (P=0.001) reflecting a U-shaped relation. MBL(2) was also significantly associated with ccIMT in a multivariable analysis adjusting for traditional and RA related cardiovascular risk modifiers (P=0.025). CONCLUSION: In RA patients, a quadratic U-shaped relation between serum MBL and ccIMT was observed independently of the effects of traditional and RA related risk factors for CVD. These results provide further support to the notion that both high and low levels of MBL may be associated with CVD.
U2 - 10.1016/j.molimm.2009.10.021
DO - 10.1016/j.molimm.2009.10.021
M3 - Journal article
C2 - 19939454
VL - 47
SP - 713
EP - 718
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
IS - 4
ER -
ID: 19440135