Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging?

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Standard

Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging? / Felbo, Sara Kamp; Wiell, Charlotte; Østergaard, Mikkel; Poggenborg, René Panduro; Bøyesen, Pernille; Hammer, Hilde Berner; Boonen, Annelies; Pedersen, Susanne Juhl; Sørensen, Inge Juul; Madsen, Ole Rintek; Slot, Ole; Møller, Jakob Møllenbach; Szkudlarek, Marcin; Terslev, Lene.

I: Rheumatology (Oxford, England), Bind 61, Nr. 2, 2022, s. 723-733.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Felbo, SK, Wiell, C, Østergaard, M, Poggenborg, RP, Bøyesen, P, Hammer, HB, Boonen, A, Pedersen, SJ, Sørensen, IJ, Madsen, OR, Slot, O, Møller, JM, Szkudlarek, M & Terslev, L 2022, 'Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging?', Rheumatology (Oxford, England), bind 61, nr. 2, s. 723-733. https://doi.org/10.1093/rheumatology/keab384

APA

Felbo, S. K., Wiell, C., Østergaard, M., Poggenborg, R. P., Bøyesen, P., Hammer, H. B., Boonen, A., Pedersen, S. J., Sørensen, I. J., Madsen, O. R., Slot, O., Møller, J. M., Szkudlarek, M., & Terslev, L. (2022). Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging? Rheumatology (Oxford, England), 61(2), 723-733. https://doi.org/10.1093/rheumatology/keab384

Vancouver

Felbo SK, Wiell C, Østergaard M, Poggenborg RP, Bøyesen P, Hammer HB o.a. Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging? Rheumatology (Oxford, England). 2022;61(2):723-733. https://doi.org/10.1093/rheumatology/keab384

Author

Felbo, Sara Kamp ; Wiell, Charlotte ; Østergaard, Mikkel ; Poggenborg, René Panduro ; Bøyesen, Pernille ; Hammer, Hilde Berner ; Boonen, Annelies ; Pedersen, Susanne Juhl ; Sørensen, Inge Juul ; Madsen, Ole Rintek ; Slot, Ole ; Møller, Jakob Møllenbach ; Szkudlarek, Marcin ; Terslev, Lene. / Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging?. I: Rheumatology (Oxford, England). 2022 ; Bind 61, Nr. 2. s. 723-733.

Bibtex

@article{7dd10a9333dc483d8bfaec89b66cf323,
title = "Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging?",
abstract = "OBJECTIVE: To investigate the association between clinical joint tenderness and intra- and periarticular inflammation as assessed by ultrasound and MRI in patients with active PsA and to explore if the associations differ according to patient-reported outcomes (PROs) and structural damage. METHODS: Forty-one patients with active PsA and hand involvement had 76/78 joints examined for swelling/tenderness and ultrasound and MRI of 24 and 12 finger joints, respectively. Synovitis, tenosynovitis, periarticular inflammation and erosions were assessed using OMERACT definitions and scoring systems. Correlation between imaging inflammation sum-scores (intra-and periarticular) and tender/swollen joint counts were calculated using Spearman's rho, agreement at joint level was examined using prevalence and bias adjusted kappa (PABAK). Subgroup analyses explored the influence of PROs and radiographic erosive disease on these associations. RESULTS: No significant correlations were found between tender or swollen joint counts and imaging inflammation sum-scores (rho = -0.31-0.38). In patients with higher level of overall pain, disability and lower self-reported mental health, a tendency towards negative correlations were found. At joint level, intra- and periarticular imaging inflammatory lesions had slight agreement with joint tenderness (PABAK = 0.02-0.19) and slight to moderate with swelling (PABAK = 0.16-0.54). For tender joints, agreement with imaging inflammation was even weaker in patients with either high overall pain scores, high disability scores, and/or non-erosive disease. CONCLUSION: Joint tenderness had low association with imaging signs of inflammation in PsA patients, particularly in patients with high self-reported pain, disability and low mental health, indicating that tenderness is influenced by other parameters than local inflammation.",
keywords = "magnetic resonance imaging, patient-reported outcomes, psoriatic arthritis, tender joints, ultrasound",
author = "Felbo, {Sara Kamp} and Charlotte Wiell and Mikkel {\O}stergaard and Poggenborg, {Ren{\'e} Panduro} and Pernille B{\o}yesen and Hammer, {Hilde Berner} and Annelies Boonen and Pedersen, {Susanne Juhl} and S{\o}rensen, {Inge Juul} and Madsen, {Ole Rintek} and Ole Slot and M{\o}ller, {Jakob M{\o}llenbach} and Marcin Szkudlarek and Lene Terslev",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2022",
doi = "10.1093/rheumatology/keab384",
language = "English",
volume = "61",
pages = "723--733",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging?

AU - Felbo, Sara Kamp

AU - Wiell, Charlotte

AU - Østergaard, Mikkel

AU - Poggenborg, René Panduro

AU - Bøyesen, Pernille

AU - Hammer, Hilde Berner

AU - Boonen, Annelies

AU - Pedersen, Susanne Juhl

AU - Sørensen, Inge Juul

AU - Madsen, Ole Rintek

AU - Slot, Ole

AU - Møller, Jakob Møllenbach

AU - Szkudlarek, Marcin

AU - Terslev, Lene

N1 - Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - OBJECTIVE: To investigate the association between clinical joint tenderness and intra- and periarticular inflammation as assessed by ultrasound and MRI in patients with active PsA and to explore if the associations differ according to patient-reported outcomes (PROs) and structural damage. METHODS: Forty-one patients with active PsA and hand involvement had 76/78 joints examined for swelling/tenderness and ultrasound and MRI of 24 and 12 finger joints, respectively. Synovitis, tenosynovitis, periarticular inflammation and erosions were assessed using OMERACT definitions and scoring systems. Correlation between imaging inflammation sum-scores (intra-and periarticular) and tender/swollen joint counts were calculated using Spearman's rho, agreement at joint level was examined using prevalence and bias adjusted kappa (PABAK). Subgroup analyses explored the influence of PROs and radiographic erosive disease on these associations. RESULTS: No significant correlations were found between tender or swollen joint counts and imaging inflammation sum-scores (rho = -0.31-0.38). In patients with higher level of overall pain, disability and lower self-reported mental health, a tendency towards negative correlations were found. At joint level, intra- and periarticular imaging inflammatory lesions had slight agreement with joint tenderness (PABAK = 0.02-0.19) and slight to moderate with swelling (PABAK = 0.16-0.54). For tender joints, agreement with imaging inflammation was even weaker in patients with either high overall pain scores, high disability scores, and/or non-erosive disease. CONCLUSION: Joint tenderness had low association with imaging signs of inflammation in PsA patients, particularly in patients with high self-reported pain, disability and low mental health, indicating that tenderness is influenced by other parameters than local inflammation.

AB - OBJECTIVE: To investigate the association between clinical joint tenderness and intra- and periarticular inflammation as assessed by ultrasound and MRI in patients with active PsA and to explore if the associations differ according to patient-reported outcomes (PROs) and structural damage. METHODS: Forty-one patients with active PsA and hand involvement had 76/78 joints examined for swelling/tenderness and ultrasound and MRI of 24 and 12 finger joints, respectively. Synovitis, tenosynovitis, periarticular inflammation and erosions were assessed using OMERACT definitions and scoring systems. Correlation between imaging inflammation sum-scores (intra-and periarticular) and tender/swollen joint counts were calculated using Spearman's rho, agreement at joint level was examined using prevalence and bias adjusted kappa (PABAK). Subgroup analyses explored the influence of PROs and radiographic erosive disease on these associations. RESULTS: No significant correlations were found between tender or swollen joint counts and imaging inflammation sum-scores (rho = -0.31-0.38). In patients with higher level of overall pain, disability and lower self-reported mental health, a tendency towards negative correlations were found. At joint level, intra- and periarticular imaging inflammatory lesions had slight agreement with joint tenderness (PABAK = 0.02-0.19) and slight to moderate with swelling (PABAK = 0.16-0.54). For tender joints, agreement with imaging inflammation was even weaker in patients with either high overall pain scores, high disability scores, and/or non-erosive disease. CONCLUSION: Joint tenderness had low association with imaging signs of inflammation in PsA patients, particularly in patients with high self-reported pain, disability and low mental health, indicating that tenderness is influenced by other parameters than local inflammation.

KW - magnetic resonance imaging

KW - patient-reported outcomes

KW - psoriatic arthritis

KW - tender joints

KW - ultrasound

U2 - 10.1093/rheumatology/keab384

DO - 10.1093/rheumatology/keab384

M3 - Journal article

C2 - 33895799

AN - SCOPUS:85124435774

VL - 61

SP - 723

EP - 733

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 2

ER -

ID: 299572465