Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthermore uncovered and characterized constitutive activity of both isoforms.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Pharmacology |
Vol/bind | 159 |
Udgave nummer | 5 |
Sider (fra-til) | 1092-105 |
Antal sider | 14 |
ISSN | 0007-1188 |
DOI | |
Status | Udgivet - mar. 2010 |
ID: 48317125