TY - JOUR

T1 - Disease Mechanisms in Atopic Dermatitis

T2 - A Review of Aetiological Factors

AU - Thyssen, Jacob P

AU - Rinnov, Maria Rasmussen

AU - Vestergaard, Christian

PY - 2020/6/9

Y1 - 2020/6/9

N2 - Atopic dermatitis is a prevalent inflammatory skin condition characterized by itch and dry skin, which affects 15-20% of children and 3-5% of adults. This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermatitis. Genetic predisposition, environmental insults, atopic triggers, complex host immune response and skin barrier changes, and altered skin microbiota are discussed. Whilst our understanding of atopic dermatitis has improved dramatically in recent years, many basic aspects are still not understood. Further research is needed to fully understand this complex skin disease.

AB - Atopic dermatitis is a prevalent inflammatory skin condition characterized by itch and dry skin, which affects 15-20% of children and 3-5% of adults. This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermatitis. Genetic predisposition, environmental insults, atopic triggers, complex host immune response and skin barrier changes, and altered skin microbiota are discussed. Whilst our understanding of atopic dermatitis has improved dramatically in recent years, many basic aspects are still not understood. Further research is needed to fully understand this complex skin disease.

U2 - 10.2340/00015555-3512

DO - 10.2340/00015555-3512

M3 - Review

C2 - 32412642

VL - 100

SP - 341

EP - 348

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 12

M1 - adv00162

ER -