Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum
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Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum. / Cavanagh, D R; Dobaño, C; Elhassan, I M; Marsh, K; Elhassan, A; Hviid, L; Khalil, E A; Theander, T G; Arnot, D E; McBride, J S.
I: Infection and Immunity, Bind 69, Nr. 2, 2001, s. 1207-11.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum
AU - Cavanagh, D R
AU - Dobaño, C
AU - Elhassan, I M
AU - Marsh, K
AU - Elhassan, A
AU - Hviid, L
AU - Khalil, E A
AU - Theander, T G
AU - Arnot, D E
AU - McBride, J S
N1 - Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Infant; Merozoite Surface Protein 1; Middle Aged; Peptide Fragments; Plasmodium falciparum
PY - 2001
Y1 - 2001
N2 - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.
AB - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.
U2 - 10.1128/IAI.69.2.1207-1211.2001
DO - 10.1128/IAI.69.2.1207-1211.2001
M3 - Journal article
C2 - 11160024
VL - 69
SP - 1207
EP - 1211
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 2
ER -
ID: 6747323