Dietary fatty acids, macronutrient substitutions, food sources and incidence of coronary heart disease: Findings from the EPIC-CVD case-cohort study across nine european countries
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Dietary fatty acids, macronutrient substitutions, food sources and incidence of coronary heart disease : Findings from the EPIC-CVD case-cohort study across nine european countries. / Steur, Marinka; Johnson, Laura; Sharp, Stephen J.; Imamura, Fumiaki; Sluijs, Ivonne; Key, Timothy J.; Wood, Angela; Chowdhury, Rajiv; Guevara, Marcela; Jakobsen, Marianne U.; Johansson, Ingegerd; Koulman, Albert; Overvad, Kim; Sánchez, Maria José; van der Schouw, Yvonne T.; Trichopoulou, Antonia; Weiderpass, Elisabete; Wennberg, Maria; Zheng, Ju Sheng; Boeing, Heiner; Boer, Jolanda M.A.; Boutron-Ruault, Marie Christine; Ericson, Ulrika; Heath, Alicia K.; Huybrechts, Inge; Imaz, Liher; Kaaks, Rudolf; Krogh, Vittorio; Kühn, Tilman; Kyrø, Cecilie; Masala, Giovanna; Melander, Olle; Moreno-Iribas, Conchi; Panico, Salvatore; Quirós, José R.; Rodríguez-Barranco, Miguel; Sacerdote, Carlotta; Santiuste, Carmen; Skeie, Guri; Tjønneland, Anne; Tumino, Rosario; Monique Verschuren, W. M.; Zamora-Ros, Raul; Dahm, Christina C.; Perez-Cornago, Aurora; Schulze, Matthias B.; Tong, Tammy Y.N.; Riboli, Elio; Wareham, Nicholas J.; Danesh, John; Butterworth, Adam S.; Forouhi, Nita G.
I: Journal of the American Heart Association, Bind 10, Nr. 23, e019814, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dietary fatty acids, macronutrient substitutions, food sources and incidence of coronary heart disease
T2 - Findings from the EPIC-CVD case-cohort study across nine european countries
AU - Steur, Marinka
AU - Johnson, Laura
AU - Sharp, Stephen J.
AU - Imamura, Fumiaki
AU - Sluijs, Ivonne
AU - Key, Timothy J.
AU - Wood, Angela
AU - Chowdhury, Rajiv
AU - Guevara, Marcela
AU - Jakobsen, Marianne U.
AU - Johansson, Ingegerd
AU - Koulman, Albert
AU - Overvad, Kim
AU - Sánchez, Maria José
AU - van der Schouw, Yvonne T.
AU - Trichopoulou, Antonia
AU - Weiderpass, Elisabete
AU - Wennberg, Maria
AU - Zheng, Ju Sheng
AU - Boeing, Heiner
AU - Boer, Jolanda M.A.
AU - Boutron-Ruault, Marie Christine
AU - Ericson, Ulrika
AU - Heath, Alicia K.
AU - Huybrechts, Inge
AU - Imaz, Liher
AU - Kaaks, Rudolf
AU - Krogh, Vittorio
AU - Kühn, Tilman
AU - Kyrø, Cecilie
AU - Masala, Giovanna
AU - Melander, Olle
AU - Moreno-Iribas, Conchi
AU - Panico, Salvatore
AU - Quirós, José R.
AU - Rodríguez-Barranco, Miguel
AU - Sacerdote, Carlotta
AU - Santiuste, Carmen
AU - Skeie, Guri
AU - Tjønneland, Anne
AU - Tumino, Rosario
AU - Monique Verschuren, W. M.
AU - Zamora-Ros, Raul
AU - Dahm, Christina C.
AU - Perez-Cornago, Aurora
AU - Schulze, Matthias B.
AU - Tong, Tammy Y.N.
AU - Riboli, Elio
AU - Wareham, Nicholas J.
AU - Danesh, John
AU - Butterworth, Adam S.
AU - Forouhi, Nita G.
N1 - Publisher Copyright: © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2021
Y1 - 2021
N2 - BACKGROUND: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. METHODS AND RESULTS: We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88– 0.99]), cheese (HR, 0.98 [95% CI, 0.96–1.00]), and fish (HR, 0.87 [95% CI, 0.75–1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02–1.12]) and butter (HR, 1.02 [95% CI, 1.00–1.04]). CONCLUSIONS: This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite direc-tions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.
AB - BACKGROUND: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. METHODS AND RESULTS: We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88– 0.99]), cheese (HR, 0.98 [95% CI, 0.96–1.00]), and fish (HR, 0.87 [95% CI, 0.75–1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02–1.12]) and butter (HR, 1.02 [95% CI, 1.00–1.04]). CONCLUSIONS: This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite direc-tions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.
KW - Coronary heart disease
KW - Dietary guidelines
KW - Nutritional epidemiology
KW - Primary prevention
KW - Saturated fat
U2 - 10.1161/JAHA.120.019814
DO - 10.1161/JAHA.120.019814
M3 - Journal article
C2 - 34796724
AN - SCOPUS:85121028397
VL - 10
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 23
M1 - e019814
ER -
ID: 287755863