Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers: the Eurodiale study
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Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers : the Eurodiale study. / Siersma, Volkert; Thorsen, Hanne; Holstein, Per E.; Kars, Marleen; Apelqvist, Jan; Jude, Edward B.; Piaggesi, Alberto; Bakker, Karel; Edmonds, Michael; Jirkovská, Alexandra; Mauricio, Didac; Reike, Heinrich; Spraul, Maximilian; Uccioli, Luigi; Urbancic, Vilma; van Acker, Kristien; van Baal, Jeff; Schaper, Nicolaas C.
I: Journal of Diabetes and its Complications, Bind 31, Nr. 7, 07.2017, s. 1145-1151.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers
T2 - the Eurodiale study
AU - Siersma, Volkert
AU - Thorsen, Hanne
AU - Holstein, Per E.
AU - Kars, Marleen
AU - Apelqvist, Jan
AU - Jude, Edward B.
AU - Piaggesi, Alberto
AU - Bakker, Karel
AU - Edmonds, Michael
AU - Jirkovská, Alexandra
AU - Mauricio, Didac
AU - Reike, Heinrich
AU - Spraul, Maximilian
AU - Uccioli, Luigi
AU - Urbancic, Vilma
AU - van Acker, Kristien
AU - van Baal, Jeff
AU - Schaper, Nicolaas C.
PY - 2017/7
Y1 - 2017/7
N2 - Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment. Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics. Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly. Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers.
AB - Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment. Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics. Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly. Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers.
KW - Comorbidity
KW - Diabetes mellitus
KW - Diabetic foot ulcer
KW - Health-related quality of life
KW - Longitudinal study
U2 - 10.1016/j.jdiacomp.2017.04.008
DO - 10.1016/j.jdiacomp.2017.04.008
M3 - Journal article
C2 - 28457703
AN - SCOPUS:85018320443
VL - 31
SP - 1145
EP - 1151
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 7
ER -
ID: 179047724