Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder
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Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder. / Veddum, Lotte; Greve, Aja Neergaard; Andreassen, Anna Krogh; Knudsen, Christina Bruun; Brandt, Julie Marie; Gregersen, Maja; Krantz, Mette Falkenberg; Søndergaard, Anne; Ohland, Jessica; Burton, Birgitte Klee; Jepsen, Jens Richardt Møllegaard; Hemager, Nicoline; Thorup, Anne Amalie Elgaard; Nordentoft, Merete; Mors, Ole; Bliksted, Vibeke.
I: Schizophrenia Research: Cognition, Bind 28, 100242, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder
AU - Veddum, Lotte
AU - Greve, Aja Neergaard
AU - Andreassen, Anna Krogh
AU - Knudsen, Christina Bruun
AU - Brandt, Julie Marie
AU - Gregersen, Maja
AU - Krantz, Mette Falkenberg
AU - Søndergaard, Anne
AU - Ohland, Jessica
AU - Burton, Birgitte Klee
AU - Jepsen, Jens Richardt Møllegaard
AU - Hemager, Nicoline
AU - Thorup, Anne Amalie Elgaard
AU - Nordentoft, Merete
AU - Mors, Ole
AU - Bliksted, Vibeke
N1 - Publisher Copyright: © 2022 The Authors
PY - 2022
Y1 - 2022
N2 - Social impairments are suggested as vulnerability markers for schizophrenia and bipolar disorder. Therefore, we investigated the development of social responsiveness and theory of mind (ToM) in children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP). This study is part of The Danish High Risk and Resilience Study, a longitudinal cohort study of children at FHR-SZ or FHR-BP and population-based controls (PBC). Social responsiveness was measured with the Social Responsiveness Scale (SRS-2), completed by teachers and primary caregivers. ToM was measured using The Animated Triangles Task (ATT). Both SRS-2 and ATT were applied at age 7 and 11. A total of 520 children participated (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 200). Results showed no significant time by group interactions. At follow-up, children at FHR-SZ exhibited impaired social responsiveness compared with PBC regardless of the informant. At both timepoints, a higher proportion of children at FHR-SZ were rated at a clinically significant level, implying inference in everyday social interactions. Compared with PBC, primary caregivers reported impairments in social responsiveness in children at FHR-BP at follow-up. The three groups did not differ in ToM at follow-up. Social responsiveness and ToM do not develop differently in children at FHR-SZ, FHR-BP and PBC from age 7 to 11, but impairments in social responsiveness remain stable and may constitute a vulnerability marker particularly in children at FHR-SZ, but also FHR-BP. ToM abilities seem to improve and remain intact, but ToM development and ToM task properties should be taken into consideration.
AB - Social impairments are suggested as vulnerability markers for schizophrenia and bipolar disorder. Therefore, we investigated the development of social responsiveness and theory of mind (ToM) in children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP). This study is part of The Danish High Risk and Resilience Study, a longitudinal cohort study of children at FHR-SZ or FHR-BP and population-based controls (PBC). Social responsiveness was measured with the Social Responsiveness Scale (SRS-2), completed by teachers and primary caregivers. ToM was measured using The Animated Triangles Task (ATT). Both SRS-2 and ATT were applied at age 7 and 11. A total of 520 children participated (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 200). Results showed no significant time by group interactions. At follow-up, children at FHR-SZ exhibited impaired social responsiveness compared with PBC regardless of the informant. At both timepoints, a higher proportion of children at FHR-SZ were rated at a clinically significant level, implying inference in everyday social interactions. Compared with PBC, primary caregivers reported impairments in social responsiveness in children at FHR-BP at follow-up. The three groups did not differ in ToM at follow-up. Social responsiveness and ToM do not develop differently in children at FHR-SZ, FHR-BP and PBC from age 7 to 11, but impairments in social responsiveness remain stable and may constitute a vulnerability marker particularly in children at FHR-SZ, but also FHR-BP. ToM abilities seem to improve and remain intact, but ToM development and ToM task properties should be taken into consideration.
KW - Bipolar disorder
KW - High-risk
KW - Offspring
KW - Schizophrenia
KW - Social responsiveness
KW - Theory of mind
U2 - 10.1016/j.scog.2022.100242
DO - 10.1016/j.scog.2022.100242
M3 - Journal article
C2 - 35242611
AN - SCOPUS:85125130989
VL - 28
JO - Schizophrenia Research: Cognition
JF - Schizophrenia Research: Cognition
SN - 2215-0013
M1 - 100242
ER -
ID: 299556425