Development of semiquantitative ultrasound scoring system to assess cartilage in rheumatoid arthritis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Development of semiquantitative ultrasound scoring system to assess cartilage in rheumatoid arthritis. / Mandl, Peter; Studenic, Paul; Filippucci, Emilio; Bachta, Artur; Backhaus, Marina; Bong, David; Bruyn, George A.W.; Collado, Paz; Damjanov, Nemanja; Dejaco, Christian; Delle-Sedie, Andrea; De Miguel, Eugenio; Duftner, Christina; Gessl, Irina; Gutierrez, Marwin; Hammer, Hilde B.; Hernandez-Diaz, Cristina; Iagnocco, Annmaria; Ikeda, Kei; Kane, David; Keen, Helen; Kelly, Stephen; Kovári, Eszter; Möller, Ingrid; Møller-Dohn, Uffe; Naredo, Esperanza; Nieto, Juan C.; Pineda, Carlos; Platzer, Alex; Rodriguez, Ana; Schmidt, Wolfgang A.; Supp, Gabriela; Szkudlarek, Marcin; Terslev, Lene; Thiele, Ralf; Wakefield, Richard J.; Windschall, Daniel; D'Agostino, Maria Antonietta; Balint, Peter V.
I: Rheumatology, Bind 58, Nr. 10, 2019, s. 1802-1811.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Development of semiquantitative ultrasound scoring system to assess cartilage in rheumatoid arthritis
AU - Mandl, Peter
AU - Studenic, Paul
AU - Filippucci, Emilio
AU - Bachta, Artur
AU - Backhaus, Marina
AU - Bong, David
AU - Bruyn, George A.W.
AU - Collado, Paz
AU - Damjanov, Nemanja
AU - Dejaco, Christian
AU - Delle-Sedie, Andrea
AU - De Miguel, Eugenio
AU - Duftner, Christina
AU - Gessl, Irina
AU - Gutierrez, Marwin
AU - Hammer, Hilde B.
AU - Hernandez-Diaz, Cristina
AU - Iagnocco, Annmaria
AU - Ikeda, Kei
AU - Kane, David
AU - Keen, Helen
AU - Kelly, Stephen
AU - Kovári, Eszter
AU - Möller, Ingrid
AU - Møller-Dohn, Uffe
AU - Naredo, Esperanza
AU - Nieto, Juan C.
AU - Pineda, Carlos
AU - Platzer, Alex
AU - Rodriguez, Ana
AU - Schmidt, Wolfgang A.
AU - Supp, Gabriela
AU - Szkudlarek, Marcin
AU - Terslev, Lene
AU - Thiele, Ralf
AU - Wakefield, Richard J.
AU - Windschall, Daniel
AU - D'Agostino, Maria Antonietta
AU - Balint, Peter V.
PY - 2019
Y1 - 2019
N2 - To develop and test the reliability of a new semiquantitative scoring system for the assessment of cartilage changes by ultrasound in a web-based exercise as well as a patient exercise of patients with RA. Methods: A taskforce of the Outcome Measures in Rheumatology Ultrasound Working Group performed a systematic literature review on the US assessment of cartilage in RA, followed by a Delphi survey on cartilage changes and a new semiquantitative US scoring system, and finally a web-based exercise as well as a patient exercise. For the web-based exercise, taskforce members scored a dataset of anonymized static images of MCP joints in RA patients and healthy controls, which also contained duplicate images. Subsequently, 12 taskforce members used the same US to score cartilage in MCP and proximal interphalangeal joints of six patients with RA in in a patient reliability exercise. Percentage agreement and prevalence of lesions were calculated, as intrareader reliability was assessed by weighted kappa and interreader reliability by Light's kappa. Results: The three-grade semiquantitative scoring system demonstrated excellent intrareader reliability (kappa: 0.87 and 0.83) in the web-based exercise and the patient exercise, respectively. Interreader reliability was good in the web-based exercise (kappa: 0.64) and moderate (kappa: 0.48) in the patient exercise. Conclusion: Our study demonstrates that ultrasound is a reliable tool for evaluating cartilage changes in the MCP joints of patients with RA and supports further development of a new reliable semiquantitative ultrasound scoring system for evaluating cartilage involvement in RA.
AB - To develop and test the reliability of a new semiquantitative scoring system for the assessment of cartilage changes by ultrasound in a web-based exercise as well as a patient exercise of patients with RA. Methods: A taskforce of the Outcome Measures in Rheumatology Ultrasound Working Group performed a systematic literature review on the US assessment of cartilage in RA, followed by a Delphi survey on cartilage changes and a new semiquantitative US scoring system, and finally a web-based exercise as well as a patient exercise. For the web-based exercise, taskforce members scored a dataset of anonymized static images of MCP joints in RA patients and healthy controls, which also contained duplicate images. Subsequently, 12 taskforce members used the same US to score cartilage in MCP and proximal interphalangeal joints of six patients with RA in in a patient reliability exercise. Percentage agreement and prevalence of lesions were calculated, as intrareader reliability was assessed by weighted kappa and interreader reliability by Light's kappa. Results: The three-grade semiquantitative scoring system demonstrated excellent intrareader reliability (kappa: 0.87 and 0.83) in the web-based exercise and the patient exercise, respectively. Interreader reliability was good in the web-based exercise (kappa: 0.64) and moderate (kappa: 0.48) in the patient exercise. Conclusion: Our study demonstrates that ultrasound is a reliable tool for evaluating cartilage changes in the MCP joints of patients with RA and supports further development of a new reliable semiquantitative ultrasound scoring system for evaluating cartilage involvement in RA.
KW - cartilage
KW - rheumatoid arthritis
KW - ultrasound
U2 - 10.1093/rheumatology/kez153
DO - 10.1093/rheumatology/kez153
M3 - Journal article
C2 - 31034077
AN - SCOPUS:85072627853
VL - 58
SP - 1802
EP - 1811
JO - Rheumatology
JF - Rheumatology
SN - 1462-0324
IS - 10
ER -
ID: 235781521