Determining Persistence with an Inhaled Corticosteroid in Asthma: Assessment Using an Objective Measurement vs the Self-Reported Foster Score
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Determining Persistence with an Inhaled Corticosteroid in Asthma : Assessment Using an Objective Measurement vs the Self-Reported Foster Score. / Hedegaard, Britt Overgaard; Hakansson, Kjell Erik Julius; Jensen, Frodi Fridason; Ulrik, Charlotte Suppli; Weinreich, Ulla Moller.
I: Journal of Asthma and Allergy, Bind 15, 2022, s. 25-33.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Determining Persistence with an Inhaled Corticosteroid in Asthma
T2 - Assessment Using an Objective Measurement vs the Self-Reported Foster Score
AU - Hedegaard, Britt Overgaard
AU - Hakansson, Kjell Erik Julius
AU - Jensen, Frodi Fridason
AU - Ulrik, Charlotte Suppli
AU - Weinreich, Ulla Moller
PY - 2022
Y1 - 2022
N2 - Introduction: Adherence with controller medication is a major challenge in asthma management. Thus, a reliable method of measurement is mandatory to assess adherence.Aim: To examine the test-retest reliability on adherence with inhaled corticosteroids in adults with asthma using, a self-reported adherence score (Foster score).Methods: Patients with asthma and >1 routine follow-up appointment at a university hospital outpatient clinic reported Foster scores. The objective Medication Possession Ratio (MPR) was calculated based on pharmacy redemption data and physician-prescribed doses of inhaled corticosteroids. The difference between Foster score and MPR at the first and second visit was assessed using a Bland-Altman plot, outcomes reported as limits of agreements and bias. Foster scores from both visits were used to calculate an intraclass correlation coefficient (ICC).Results: Self-reported adherence with asthma controller medication measured by Foster score was significantly higher than the objective MPR (p < 0.0001). The Bland-Altman plot for MPR and Foster score at the first and second visit showed upper and lower limits of agreement of 83.5 - (-1.6) and 80.9 - (-6.9) and bias was 41.0 and 37.0, respectively. Of the included patients, 93.1% reported identical Foster scores between visits, resulting in an excellent ICC of 0.92. Absolute median difference between Foster scores and MPR at first and second visit was 8.7 percentage points (p = 0.049).Conclusion: Foster score shows an excellent ICC; however, its poor agreement with objective measures of adherence suggests that clinicians should not rely on Foster
AB - Introduction: Adherence with controller medication is a major challenge in asthma management. Thus, a reliable method of measurement is mandatory to assess adherence.Aim: To examine the test-retest reliability on adherence with inhaled corticosteroids in adults with asthma using, a self-reported adherence score (Foster score).Methods: Patients with asthma and >1 routine follow-up appointment at a university hospital outpatient clinic reported Foster scores. The objective Medication Possession Ratio (MPR) was calculated based on pharmacy redemption data and physician-prescribed doses of inhaled corticosteroids. The difference between Foster score and MPR at the first and second visit was assessed using a Bland-Altman plot, outcomes reported as limits of agreements and bias. Foster scores from both visits were used to calculate an intraclass correlation coefficient (ICC).Results: Self-reported adherence with asthma controller medication measured by Foster score was significantly higher than the objective MPR (p < 0.0001). The Bland-Altman plot for MPR and Foster score at the first and second visit showed upper and lower limits of agreement of 83.5 - (-1.6) and 80.9 - (-6.9) and bias was 41.0 and 37.0, respectively. Of the included patients, 93.1% reported identical Foster scores between visits, resulting in an excellent ICC of 0.92. Absolute median difference between Foster scores and MPR at first and second visit was 8.7 percentage points (p = 0.049).Conclusion: Foster score shows an excellent ICC; however, its poor agreement with objective measures of adherence suggests that clinicians should not rely on Foster
KW - Foster score
KW - medication possession ratio
KW - controller medication
KW - asthma
KW - self-assessed adherence
KW - self-reported outcome
KW - adherence
KW - persistence
KW - MEDICATION ADHERENCE
KW - VALIDATION
KW - VALIDITY
KW - OUTCOMES
KW - EXACERBATIONS
KW - RELIABILITY
KW - THERAPIES
KW - BELIEFS
KW - ADULTS
U2 - 10.2147/JAA.S332756
DO - 10.2147/JAA.S332756
M3 - Journal article
C2 - 35023932
VL - 15
SP - 25
EP - 33
JO - Journal of Asthma and Allergy
JF - Journal of Asthma and Allergy
SN - 1178-6965
ER -
ID: 290541217