TY - JOUR

T1 - Determinants of the ambulatory arterial stiffness index in 7604 subjects from 6 populations

AU - Adiyaman, Ahmet

AU - Dechering, Dirk G

AU - Boggia, José

AU - Li, Yan

AU - Hansen, Tine W

AU - Kikuya, Masahiro

AU - Björklund-Bodegård, Kristina

AU - Richart, Tom

AU - Thijs, Lutgarde

AU - Torp-Pedersen, Christian

AU - Ohkubo, Takayoshi

AU - Dolan, Eamon

AU - Imai, Yutaka

AU - Sandoya, Edgardo

AU - Ibsen, Hans

AU - Wang, Jiguang

AU - Lind, Lars

AU - O'Brien, Eoin

AU - Thien, Theo

AU - Staessen, Jan A

AU - International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Investigators

N1 - Keywords: Adult; Aged; Asian Continental Ancestry Group; Blood Pressure Monitoring, Ambulatory; China; Europe; European Continental Ancestry Group; Female; Humans; Hypertension; Japan; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Regression Analysis; Risk Factors; Sensitivity and Specificity; Uruguay

PY - 2008

Y1 - 2008

N2 - The ambulatory arterial stiffness index (AASI) is derived from 24-hour ambulatory blood pressure recordings. We investigated whether the goodness-of-fit of the AASI regression line in individual subjects (r(2)) impacts on the association of AASI with established determinants of the relation between diastolic and systolic blood pressures. We constructed the International Database on the Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (7604 participants from 6 countries). AASI was unity minus the regression slope of diastolic on systolic blood pressure in individual 24-hour ambulatory recordings. AASI correlated positively with age and 24-hour mean arterial pressure and negatively with body height and 24-hour heart rate. The single correlation coefficients and the mutually adjusted partial regression coefficients of AASI with age, height, 24-hour mean pressure, and 24-hour heart rate increased from the lowest to the highest quartile of r(2). These findings were consistent in dippers and nondippers (night:day ratio of systolic pressure >or=0.90), women and men, and in Europeans, Asians, and South Americans. The cumulative z score for the association of AASI with these determinants of the relation between diastolic and systolic blood pressures increased curvilinearly with r(2), with most of the improvement in the association occurring above the 20th percentile of r(2) (0.36). In conclusion, a better fit of the AASI regression line enhances the statistical power of analyses involving AASI as marker of arterial stiffness. An r(2) value of 0.36 might be a threshold in sensitivity analyses to improve the stratification of cardiovascular risk Udgivelsesdato: 2008/12

AB - The ambulatory arterial stiffness index (AASI) is derived from 24-hour ambulatory blood pressure recordings. We investigated whether the goodness-of-fit of the AASI regression line in individual subjects (r(2)) impacts on the association of AASI with established determinants of the relation between diastolic and systolic blood pressures. We constructed the International Database on the Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (7604 participants from 6 countries). AASI was unity minus the regression slope of diastolic on systolic blood pressure in individual 24-hour ambulatory recordings. AASI correlated positively with age and 24-hour mean arterial pressure and negatively with body height and 24-hour heart rate. The single correlation coefficients and the mutually adjusted partial regression coefficients of AASI with age, height, 24-hour mean pressure, and 24-hour heart rate increased from the lowest to the highest quartile of r(2). These findings were consistent in dippers and nondippers (night:day ratio of systolic pressure >or=0.90), women and men, and in Europeans, Asians, and South Americans. The cumulative z score for the association of AASI with these determinants of the relation between diastolic and systolic blood pressures increased curvilinearly with r(2), with most of the improvement in the association occurring above the 20th percentile of r(2) (0.36). In conclusion, a better fit of the AASI regression line enhances the statistical power of analyses involving AASI as marker of arterial stiffness. An r(2) value of 0.36 might be a threshold in sensitivity analyses to improve the stratification of cardiovascular risk Udgivelsesdato: 2008/12

U2 - 10.1161/HYPERTENSIONAHA.108.119511

DO - 10.1161/HYPERTENSIONAHA.108.119511

M3 - Journal article

C2 - 19001188

VL - 52

SP - 1038

EP - 1044

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 6

ER -