Detecting selection needs comparative data
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Detecting selection needs comparative data. / Nielsen, Rasmus; Hubisz, Melissa J.
I: Nature, Bind 433, Nr. 7023, 2005, s. E6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Detecting selection needs comparative data
AU - Nielsen, Rasmus
AU - Hubisz, Melissa J.
PY - 2005
Y1 - 2005
N2 - Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.
AB - Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.
U2 - 10.1038/nature03222
DO - 10.1038/nature03222
M3 - Journal article
C2 - 15662372
VL - 433
SP - E6
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7023
ER -
ID: 87075