Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Currently, most of the approved protein and peptide-based medicines are delivered via conventional parenteral injection (intramuscular, subcutaneous or intravenous). A frequent dosing regimen is often necessary because of their short plasma half-lives, causing poor patient compliance (e.g. pain, abscess, etc.), side effects owing to typical peak-valley plasma concentration time profiles, and increased costs. Among many sustained-release formulations poly lactic-co-glycolic acid (PLGA)-based depot microparticle systems may represent one of the most promising approaches to provide protein and peptide drugs with a steady pharmacokinetic/pharmacodynamic profile maintained for a long period. However, the development of PLGA-based microparticle systems is still impeded by lack of easy, fast, effective manufacturing technologies. The aim of this paper is to review recent advances in spray drying, a one-step, continuous microencapsulation process, for manufacturing of PLGA-based depot microparticle systems with a focus on the recent efforts on understanding of the role of nozzle design in the microencapsulation of proteins/peptides, and the effect of critical solvent properties and process parameters on the critical quality attributes of the spray-dried microparticles.
Originalsprog | Engelsk |
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Tidsskrift | International Journal of Pharmaceutics |
Vol/bind | 498 |
Udgave nummer | 1-2 |
Sider (fra-til) | 82-95 |
Antal sider | 14 |
ISSN | 0378-5173 |
DOI | |
Status | Udgivet - 10 feb. 2016 |
ID: 169413816