Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors
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Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. / Turner, William W; Hartvigsen, Karsten; Boullier, Agnes; Montano, Erica N; Witztum, Joseph L; VanNieuwenhze, Michael S.
I: Journal of Medicinal Chemistry, Bind 55, Nr. 18, 27.09.2012, s. 8178-82.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors
AU - Turner, William W
AU - Hartvigsen, Karsten
AU - Boullier, Agnes
AU - Montano, Erica N
AU - Witztum, Joseph L
AU - VanNieuwenhze, Michael S
PY - 2012/9/27
Y1 - 2012/9/27
N2 - Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.
AB - Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.
KW - Animals
KW - Antibodies, Monoclonal
KW - Antigens, CD36
KW - Biomimetic Materials
KW - Chemistry Techniques, Synthetic
KW - Drug Design
KW - Drug Stability
KW - Humans
KW - Mice
KW - Oxidation-Reduction
KW - Phospholipid Ethers
KW - Protein Binding
KW - Solubility
KW - Substrate Specificity
KW - Water
U2 - 10.1021/jm300685s
DO - 10.1021/jm300685s
M3 - Journal article
C2 - 22934615
VL - 55
SP - 8178
EP - 8182
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 18
ER -
ID: 47720152