Descending Command Neurons in the Brainstem that Halt Locomotion
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Descending Command Neurons in the Brainstem that Halt Locomotion. / Bouvier, Julien; Caggiano, Vittorio; Leiras, Roberto; Caldeira, Vanessa; Bellardita, Carmelo; Balueva, Kira; Fuchs, Andrea; Kiehn, Ole.
I: Cell, Bind 163, Nr. 5, 19.11.2015, s. 1191-1203.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Descending Command Neurons in the Brainstem that Halt Locomotion
AU - Bouvier, Julien
AU - Caggiano, Vittorio
AU - Leiras, Roberto
AU - Caldeira, Vanessa
AU - Bellardita, Carmelo
AU - Balueva, Kira
AU - Fuchs, Andrea
AU - Kiehn, Ole
PY - 2015/11/19
Y1 - 2015/11/19
N2 - Summary The episodic nature of locomotion is thought to be controlled by descending inputs from the brainstem. Most studies have largely attributed this control to initiating excitatory signals, but little is known about putative commands that may specifically determine locomotor offset. To link identifiable brainstem populations to a potential locomotor stop signal, we used developmental genetics and considered a discrete neuronal population in the reticular formation: the V2a neurons. We find that those neurons constitute a major excitatory pathway to locomotor areas of the ventral spinal cord. Selective activation of V2a neurons of the rostral medulla stops ongoing locomotor activity, owing to an inhibition of premotor locomotor networks in the spinal cord. Moreover, inactivation of such neurons decreases spontaneous stopping in vivo. Therefore, the V2a "stop neurons" represent a glutamatergic descending pathway that favors immobility and may thus help control the episodic nature of locomotion.
AB - Summary The episodic nature of locomotion is thought to be controlled by descending inputs from the brainstem. Most studies have largely attributed this control to initiating excitatory signals, but little is known about putative commands that may specifically determine locomotor offset. To link identifiable brainstem populations to a potential locomotor stop signal, we used developmental genetics and considered a discrete neuronal population in the reticular formation: the V2a neurons. We find that those neurons constitute a major excitatory pathway to locomotor areas of the ventral spinal cord. Selective activation of V2a neurons of the rostral medulla stops ongoing locomotor activity, owing to an inhibition of premotor locomotor networks in the spinal cord. Moreover, inactivation of such neurons decreases spontaneous stopping in vivo. Therefore, the V2a "stop neurons" represent a glutamatergic descending pathway that favors immobility and may thus help control the episodic nature of locomotion.
U2 - 10.1016/j.cell.2015.10.074
DO - 10.1016/j.cell.2015.10.074
M3 - Journal article
C2 - 26590422
AN - SCOPUS:84947727168
VL - 163
SP - 1191
EP - 1203
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -
ID: 194976760