Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model
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Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. / Frederiksen, Marie; Vorkamp, Katrin; Jensen, Niels Martin; Sorensen, Jens Ahm; Knudsen, Lisbeth E.; Sørensen, Lars S.; Webster, Thomas F.; Nielsen, Jesper B.
I: Chemosphere, Bind 162, 11.2016, s. 308-314.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model
AU - Frederiksen, Marie
AU - Vorkamp, Katrin
AU - Jensen, Niels Martin
AU - Sorensen, Jens Ahm
AU - Knudsen, Lisbeth E.
AU - Sørensen, Lars S.
AU - Webster, Thomas F.
AU - Nielsen, Jesper B.
PY - 2016/11
Y1 - 2016/11
N2 - The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.
AB - The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.
KW - NBFR
KW - Brominated flame retardants
KW - HBCDD
KW - Skin deposition
KW - Dermal exposure
KW - Dechlorane plus
U2 - 10.1016/j.chemosphere.2016.07.100
DO - 10.1016/j.chemosphere.2016.07.100
M3 - Journal article
C2 - 27513551
VL - 162
SP - 308
EP - 314
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
ER -
ID: 166939959