Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis

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Standard

Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. / Lerdrup, Mads; Holmberg, Christian Henrik; Dietrich, Nikolaj; Shaulian, E.; Herdegen, T.; Jaattela, Marja; Kallunki, T.

I: Biochimica et Biophysica Acta - Molecular Cell Research, Bind 1745, Nr. 1, 2005, s. 29-37.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lerdrup, M, Holmberg, CH, Dietrich, N, Shaulian, E, Herdegen, T, Jaattela, M & Kallunki, T 2005, 'Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis', Biochimica et Biophysica Acta - Molecular Cell Research, bind 1745, nr. 1, s. 29-37. https://doi.org/10.1016/j.bbamcr.2005.06.008

APA

Lerdrup, M., Holmberg, C. H., Dietrich, N., Shaulian, E., Herdegen, T., Jaattela, M., & Kallunki, T. (2005). Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. Biochimica et Biophysica Acta - Molecular Cell Research, 1745(1), 29-37. https://doi.org/10.1016/j.bbamcr.2005.06.008

Vancouver

Lerdrup M, Holmberg CH, Dietrich N, Shaulian E, Herdegen T, Jaattela M o.a. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. Biochimica et Biophysica Acta - Molecular Cell Research. 2005;1745(1):29-37. https://doi.org/10.1016/j.bbamcr.2005.06.008

Author

Lerdrup, Mads ; Holmberg, Christian Henrik ; Dietrich, Nikolaj ; Shaulian, E. ; Herdegen, T. ; Jaattela, Marja ; Kallunki, T. / Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. I: Biochimica et Biophysica Acta - Molecular Cell Research. 2005 ; Bind 1745, Nr. 1. s. 29-37.

Bibtex

@article{d5991b2074c211dbbee902004c4f4f50,

title = "Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis",

abstract = "JDP2 is a ubiquitously expressed nuclear protein that efficiently represses the activity of the transcription factor AP-1. Thus far, all studies of JDP2 function have relied on the ectopic expression of the protein. In this study, we use a different approach: depletion of JDP2 from cells. Specific depletion of JDP2 resulted in p53-independent cell death that resembles apoptosis and was evident at 72 h. The death mechanism was caspase dependent as the cells could be rescued by treatment with caspase inhibitor zVAD. Our studies suggest that JDP2 functions as a general survival protein, not only following UV-irradiation, as reported earlier, but also under normal culture conditions. Thus, our data support that JDP2 is a cellular survival protein whose presence is necessary for normal cellular function.",

author = "Mads Lerdrup and Holmberg, {Christian Henrik} and Nikolaj Dietrich and E. Shaulian and T. Herdegen and Marja Jaattela and T. Kallunki",

note = "Keywords: JDP2; AP-1; Programmed cell death; Caspase; Antisense",

year = "2005",

doi = "10.1016/j.bbamcr.2005.06.008",

language = "English",

volume = "1745",

pages = "29--37",

journal = "B B A - Molecular Cell Research",

issn = "0167-4889",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis

AU - Lerdrup, Mads

AU - Holmberg, Christian Henrik

AU - Dietrich, Nikolaj

AU - Shaulian, E.

AU - Herdegen, T.

AU - Jaattela, Marja

AU - Kallunki, T.

N1 - Keywords: JDP2; AP-1; Programmed cell death; Caspase; Antisense

PY - 2005

Y1 - 2005

N2 - JDP2 is a ubiquitously expressed nuclear protein that efficiently represses the activity of the transcription factor AP-1. Thus far, all studies of JDP2 function have relied on the ectopic expression of the protein. In this study, we use a different approach: depletion of JDP2 from cells. Specific depletion of JDP2 resulted in p53-independent cell death that resembles apoptosis and was evident at 72 h. The death mechanism was caspase dependent as the cells could be rescued by treatment with caspase inhibitor zVAD. Our studies suggest that JDP2 functions as a general survival protein, not only following UV-irradiation, as reported earlier, but also under normal culture conditions. Thus, our data support that JDP2 is a cellular survival protein whose presence is necessary for normal cellular function.

AB - JDP2 is a ubiquitously expressed nuclear protein that efficiently represses the activity of the transcription factor AP-1. Thus far, all studies of JDP2 function have relied on the ectopic expression of the protein. In this study, we use a different approach: depletion of JDP2 from cells. Specific depletion of JDP2 resulted in p53-independent cell death that resembles apoptosis and was evident at 72 h. The death mechanism was caspase dependent as the cells could be rescued by treatment with caspase inhibitor zVAD. Our studies suggest that JDP2 functions as a general survival protein, not only following UV-irradiation, as reported earlier, but also under normal culture conditions. Thus, our data support that JDP2 is a cellular survival protein whose presence is necessary for normal cellular function.

U2 - 10.1016/j.bbamcr.2005.06.008

DO - 10.1016/j.bbamcr.2005.06.008

M3 - Journal article

C2 - 16026868

VL - 1745

SP - 29

EP - 37

JO - B B A - Molecular Cell Research

JF - B B A - Molecular Cell Research

SN - 0167-4889

IS - 1

ER -

ID: 83375