Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways. / Vinding, Rebecca Kofod; Rago, Daniela; Kelly, Rachel S.; Gürdeniz, Gözde; Rasmussen, Morten Arendt; Stokholm, Jakob; Bønnelykke, Klaus; Litonjua, Augusto A.; Weiss, Scott T.; Lasky-Su, Jessica; Bisgaard, Hans; Chawes, Bo Lund.
I: Metabolites, Bind 10, Nr. 9, 337, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways
AU - Vinding, Rebecca Kofod
AU - Rago, Daniela
AU - Kelly, Rachel S.
AU - Gürdeniz, Gözde
AU - Rasmussen, Morten Arendt
AU - Stokholm, Jakob
AU - Bønnelykke, Klaus
AU - Litonjua, Augusto A.
AU - Weiss, Scott T.
AU - Lasky-Su, Jessica
AU - Bisgaard, Hans
AU - Chawes, Bo Lund
PY - 2020
Y1 - 2020
N2 - The relationship between developmental milestone achievement in infancy and later cognitive function and mental health is well established, but underlying biochemical mechanisms are poorly described. Our study aims to discover pathways connected to motor milestone achievement during infancy by using untargeted plasma metabolomic profiles from 571 six-month-old children in connection with age of motor milestones achievement (Denver Developmental Index) in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother-child cohort. We used univariate regression models and multivariate modelling (Partial Least Squares Discriminant Analysis: PLS-DA) to examine the associations and the VDAART (Vitamin D Antenatal Asthma Reduction Trial) cohort for validation. The univariate analyses showed 62 metabolites associated with gross-motor milestone achievement (p<0.05) as well as the PLS-DA significantly differentiated between slow and fast milestone achievers (AUC = 0.87,p= 0.01). Higher levels of tyramine-O-sulfate in the tyrosine pathway were found in the late achievers in COPSAC (p= 0.0002) and in VDAART (p= 0.02). Furthermore, we observed that slow achievers were characterized by higher levels of fatty acids and products of fatty acids metabolism including acyl carnitines. Finally, we also observed changes in the lysine, histidine, glutamate, creatine and tryptophan pathways. Observing these metabolic changes in relation to gross-motor milestones in the first year of life, may be of importance for later cognitive function and mental health.
AB - The relationship between developmental milestone achievement in infancy and later cognitive function and mental health is well established, but underlying biochemical mechanisms are poorly described. Our study aims to discover pathways connected to motor milestone achievement during infancy by using untargeted plasma metabolomic profiles from 571 six-month-old children in connection with age of motor milestones achievement (Denver Developmental Index) in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother-child cohort. We used univariate regression models and multivariate modelling (Partial Least Squares Discriminant Analysis: PLS-DA) to examine the associations and the VDAART (Vitamin D Antenatal Asthma Reduction Trial) cohort for validation. The univariate analyses showed 62 metabolites associated with gross-motor milestone achievement (p<0.05) as well as the PLS-DA significantly differentiated between slow and fast milestone achievers (AUC = 0.87,p= 0.01). Higher levels of tyramine-O-sulfate in the tyrosine pathway were found in the late achievers in COPSAC (p= 0.0002) and in VDAART (p= 0.02). Furthermore, we observed that slow achievers were characterized by higher levels of fatty acids and products of fatty acids metabolism including acyl carnitines. Finally, we also observed changes in the lysine, histidine, glutamate, creatine and tryptophan pathways. Observing these metabolic changes in relation to gross-motor milestones in the first year of life, may be of importance for later cognitive function and mental health.
KW - motor milestones
KW - metabolomics
KW - children
KW - neurodevelopment
KW - HYDROXYLYSYL GLYCOSIDES
KW - SCHIZOPHRENIA
KW - BIOMARKERS
KW - EXERCISE
KW - IDENTIFICATION
KW - CREATININE
KW - MUTATION
KW - COLLAGEN
KW - SERUM
KW - LEADS
U2 - 10.3390/metabo10090337
DO - 10.3390/metabo10090337
M3 - Journal article
C2 - 32824932
VL - 10
JO - Metabolites
JF - Metabolites
SN - 2218-1989
IS - 9
M1 - 337
ER -
ID: 250963464