Dangerous R loops form in the absence of H3K9 methylation
Publikation: Bidrag til tidsskrift › Letter › Forskning
Methylation of histone H3 on lysine 9 (H3K9) is a hallmark of transcriptionally inactive heterochromatin that is deregulated in pathological conditions. A new study shows that complete loss of H3K9 methylation in Caenorhabditis elegans leads to derepression of repetitive elements and formation of DNA:RNA hybrids (R loops), resulting in increased rates of repeat-specific mutation.
Originalsprog | Engelsk |
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Tidsskrift | Nature Genetics |
Vol/bind | 48 |
Udgave nummer | 11 |
Sider (fra-til) | 1299-1300 |
Antal sider | 2 |
ISSN | 1061-4036 |
DOI | |
Status | Udgivet - nov. 2016 |
ID: 169360902