Cytoplasmic mRNPs revisited: Singletons and condensates
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Cytoplasmic mRNPs revisited : Singletons and condensates. / Mateu-Regue, Angels; Nielsen, Finn Cilius; Christiansen, Jan.
I: BioEssays, Bind 42, Nr. 12, 2000097, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cytoplasmic mRNPs revisited
T2 - Singletons and condensates
AU - Mateu-Regue, Angels
AU - Nielsen, Finn Cilius
AU - Christiansen, Jan
PY - 2020
Y1 - 2020
N2 - Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.
AB - Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.
KW - biomolecular condensates
KW - mRNA transport
KW - mRNP granules
KW - P‐
KW - bodies
KW - RNA regulons
KW - singletons
KW - stress granules
KW - CAP-BINDING PROTEIN
KW - TRANSLATION INITIATION COMPLEX
KW - MESSENGER-RNA TRANSLATION
KW - CLOSED-LOOP MODEL
KW - P-BODIES
KW - STRESS GRANULES
KW - PROCESSING BODIES
KW - EMERGING ROLES
KW - REVEALS
KW - ORGANIZATION
U2 - 10.1002/bies.202000097
DO - 10.1002/bies.202000097
M3 - Journal article
C2 - 33145808
VL - 42
JO - BioEssays
JF - BioEssays
SN - 0265-9247
IS - 12
M1 - 2000097
ER -
ID: 251734263