Cystoscopy Accuracy in Detecting Bladder Tumors: A Prospective Video-Confirmed Study
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Cystoscopy Accuracy in Detecting Bladder Tumors : A Prospective Video-Confirmed Study. / Guldhammer, Cathrine Silberg; Vásquez, Juan Luis; Kristensen, Vibeke Møllegaard; Norus, Thomas; Nadler, Naomi; Jensen, Jørgen Bjerggaard; Azawi, Nessn.
I: Cancers, Bind 16, Nr. 1, 160, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cystoscopy Accuracy in Detecting Bladder Tumors
T2 - A Prospective Video-Confirmed Study
AU - Guldhammer, Cathrine Silberg
AU - Vásquez, Juan Luis
AU - Kristensen, Vibeke Møllegaard
AU - Norus, Thomas
AU - Nadler, Naomi
AU - Jensen, Jørgen Bjerggaard
AU - Azawi, Nessn
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2024
Y1 - 2024
N2 - Background: Bladder cancer ranks as the 10th most common cancer globally. The diagnosis of bladder tumors typically involves cystoscopy. Objective: This study aimed to evaluate the sensitivity and specificity of cystoscopy in detecting bladder tumors within a surveillance program following a bladder cancer diagnosis. Design, Setting, and Participants: This study utilized recordings of cystoscopies conducted at the Department of Urology, Zealand University Hospital, between July 2021 and November 2022. Clinical observations were cross-referenced with pathological results or follow-up cystoscopies. Clinically negative cystoscopies were further scrutinized for potential overlooked tumors. Outcome Measurements and Statistical Analysis: Sensitivity and specificity of cystoscopy were assessed through ROC curve analysis. Results and Limitations: A total of 565 cystoscopies were recorded, with 135 indicating clinical positivity. Among 181 cystoscopies with clinically negative results that underwent a follow-up cystoscopy, 17 patients (9.4%) were subsequently diagnosed with bladder cancer, with the lesions identified in the initial cystoscopy. The sensitivity and specificity of cystoscopy in these cases were 81% and 73%, respectively. Conclusion: This trial underscores the underdiagnosis and undertreatment of bladder tumors within the current surveillance program. Additionally, aggressive malignant lesions may be overlooked, heightening the risk of disease progression. Therefore, it is recommended that cystoscopies be complemented by other diagnostic methods to ensure accurate diagnosis and proper patient treatment. Patient Summary: This study involved 316 patients who underwent video-recorded cystoscopies and subsequent follow-up. Of these patients, 181 initially exhibited no clinical signs of bladder cancer. However, upon reviewing the recorded cystoscopy, bladder cancer was identified in 17 patients (9.4%).
AB - Background: Bladder cancer ranks as the 10th most common cancer globally. The diagnosis of bladder tumors typically involves cystoscopy. Objective: This study aimed to evaluate the sensitivity and specificity of cystoscopy in detecting bladder tumors within a surveillance program following a bladder cancer diagnosis. Design, Setting, and Participants: This study utilized recordings of cystoscopies conducted at the Department of Urology, Zealand University Hospital, between July 2021 and November 2022. Clinical observations were cross-referenced with pathological results or follow-up cystoscopies. Clinically negative cystoscopies were further scrutinized for potential overlooked tumors. Outcome Measurements and Statistical Analysis: Sensitivity and specificity of cystoscopy were assessed through ROC curve analysis. Results and Limitations: A total of 565 cystoscopies were recorded, with 135 indicating clinical positivity. Among 181 cystoscopies with clinically negative results that underwent a follow-up cystoscopy, 17 patients (9.4%) were subsequently diagnosed with bladder cancer, with the lesions identified in the initial cystoscopy. The sensitivity and specificity of cystoscopy in these cases were 81% and 73%, respectively. Conclusion: This trial underscores the underdiagnosis and undertreatment of bladder tumors within the current surveillance program. Additionally, aggressive malignant lesions may be overlooked, heightening the risk of disease progression. Therefore, it is recommended that cystoscopies be complemented by other diagnostic methods to ensure accurate diagnosis and proper patient treatment. Patient Summary: This study involved 316 patients who underwent video-recorded cystoscopies and subsequent follow-up. Of these patients, 181 initially exhibited no clinical signs of bladder cancer. However, upon reviewing the recorded cystoscopy, bladder cancer was identified in 17 patients (9.4%).
KW - aggressive malignant lesions
KW - bladder cancer
KW - cystoscopy
KW - overdiagnosis
KW - overtreatment
KW - sensitivity
KW - specificity
KW - supporting methods
KW - surveillance program
KW - urine cytology
U2 - 10.3390/cancers16010160
DO - 10.3390/cancers16010160
M3 - Journal article
C2 - 38201586
AN - SCOPUS:85182240261
VL - 16
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 1
M1 - 160
ER -
ID: 381721564