Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review
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Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours : a systematic review. / Grønhøj Larsen, C; Gyldenløve, M; Jensen, D H; Therkildsen, M H; Kiss, Katalin; Norrild, B; Konge, L; von Buchwald, C.
I: B J C, Bind 110, Nr. 6, 18.03.2014, s. 1587-94.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours
T2 - a systematic review
AU - Grønhøj Larsen, C
AU - Gyldenløve, M
AU - Jensen, D H
AU - Therkildsen, M H
AU - Kiss, Katalin
AU - Norrild, B
AU - Konge, L
AU - von Buchwald, C
PY - 2014/3/18
Y1 - 2014/3/18
N2 - A significant proportion of squamous cell carcinomas of the oropharynx (OP-SCC) are related to human papillomavirus (HPV) infection and p16 overexpression. This subgroup proves better prognosis and survival but no evidence exists on the correlation between HPV and p16 overexpression based on diagnostic measures and definition of p16 overexpression. We evaluated means of p16 and HPV diagnostics, and quantified overexpression of p16 in HPV-positive and -negative OP-SCCs by mode of immunohistochemical staining of carcinoma cells.
AB - A significant proportion of squamous cell carcinomas of the oropharynx (OP-SCC) are related to human papillomavirus (HPV) infection and p16 overexpression. This subgroup proves better prognosis and survival but no evidence exists on the correlation between HPV and p16 overexpression based on diagnostic measures and definition of p16 overexpression. We evaluated means of p16 and HPV diagnostics, and quantified overexpression of p16 in HPV-positive and -negative OP-SCCs by mode of immunohistochemical staining of carcinoma cells.
U2 - 10.1038/bjc.2014.42
DO - 10.1038/bjc.2014.42
M3 - Journal article
C2 - 24518594
VL - 110
SP - 1587
EP - 1594
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
IS - 6
ER -
ID: 109650743