Copeptin levels and invasive hemodynamics in patients with advanced heart failure
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Copeptin levels and invasive hemodynamics in patients with advanced heart failure. / Balling, Louise; Goetze, Jens Peter; Jung, Mette Holme; Rossing, Kasper; Boesgaard, Soeren; Gustafsson, Finn.
I: Biomarkers in Medicine, Bind 12, Nr. 8, 2018, s. 861-870.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Copeptin levels and invasive hemodynamics in patients with advanced heart failure
AU - Balling, Louise
AU - Goetze, Jens Peter
AU - Jung, Mette Holme
AU - Rossing, Kasper
AU - Boesgaard, Soeren
AU - Gustafsson, Finn
PY - 2018
Y1 - 2018
N2 - AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.
AB - AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.
U2 - 10.2217/bmm-2017-0439
DO - 10.2217/bmm-2017-0439
M3 - Journal article
C2 - 30058349
VL - 12
SP - 861
EP - 870
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
SN - 1752-0363
IS - 8
ER -
ID: 221266199