Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes. / Stahl-Meyer, Jonathan; Stahl-Meyer, Kamilla; Jäättelä, Marja.

I: Current Opinion in Cell Biology, Bind 71, 2021, s. 29-37.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Stahl-Meyer, J, Stahl-Meyer, K & Jäättelä, M 2021, 'Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes', Current Opinion in Cell Biology, bind 71, s. 29-37. https://doi.org/10.1016/j.ceb.2021.02.003

APA

Stahl-Meyer, J., Stahl-Meyer, K., & Jäättelä, M. (2021). Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes. Current Opinion in Cell Biology, 71, 29-37. https://doi.org/10.1016/j.ceb.2021.02.003

Vancouver

Stahl-Meyer J, Stahl-Meyer K, Jäättelä M. Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes. Current Opinion in Cell Biology. 2021;71:29-37. https://doi.org/10.1016/j.ceb.2021.02.003

Author

Stahl-Meyer, Jonathan ; Stahl-Meyer, Kamilla ; Jäättelä, Marja. / Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes. I: Current Opinion in Cell Biology. 2021 ; Bind 71. s. 29-37.

Bibtex

@article{12fd68792a234a84a2c17d0e8b863254,

title = "Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes",

abstract = "Lysosomal membrane permeabilization and subsequent leakage of lysosomal hydrolases into the cytosol are considered as the major hallmarks of evolutionarily conserved lysosome-dependent cell death. Contradicting this postulate, new sensitive methods that can detect a minimal lysosomal membrane damage have demonstrated that lysosomal leakage does not necessarily equal cell death. Notably, cells are not only able to survive minor lysosomal membrane permeabilization, but some of their normal functions actually depend on leaked lysosomal hydrolases. Here we discuss emerging data suggesting that spatially and temporally controlled lysosomal leakage delivers lysosomal hydrolases to specific subcellular sites of action and controls at least three essential cellular processes, namely mitotic chromosome segregation, inflammatory signaling, and cellular motility.",

keywords = "Adhesion, Cathepsins, Chromosome segregation, Inflammation, Lysosomal membrane permeabilization, Lysosomal storage disorders, Lysosome, Mitosis, Motility, NLRP3 inflammasome",

author = "Jonathan Stahl-Meyer and Kamilla Stahl-Meyer and Marja J{\"a}{\"a}ttel{\"a}",

year = "2021",

doi = "10.1016/j.ceb.2021.02.003",

language = "English",

volume = "71",

pages = "29--37",

journal = "Current Opinion in Cell Biology",

issn = "0955-0674",

publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Control of mitosis, inflammation, and cell motility by limited leakage of lysosomes

AU - Stahl-Meyer, Jonathan

AU - Stahl-Meyer, Kamilla

AU - Jäättelä, Marja

PY - 2021

Y1 - 2021

N2 - Lysosomal membrane permeabilization and subsequent leakage of lysosomal hydrolases into the cytosol are considered as the major hallmarks of evolutionarily conserved lysosome-dependent cell death. Contradicting this postulate, new sensitive methods that can detect a minimal lysosomal membrane damage have demonstrated that lysosomal leakage does not necessarily equal cell death. Notably, cells are not only able to survive minor lysosomal membrane permeabilization, but some of their normal functions actually depend on leaked lysosomal hydrolases. Here we discuss emerging data suggesting that spatially and temporally controlled lysosomal leakage delivers lysosomal hydrolases to specific subcellular sites of action and controls at least three essential cellular processes, namely mitotic chromosome segregation, inflammatory signaling, and cellular motility.

AB - Lysosomal membrane permeabilization and subsequent leakage of lysosomal hydrolases into the cytosol are considered as the major hallmarks of evolutionarily conserved lysosome-dependent cell death. Contradicting this postulate, new sensitive methods that can detect a minimal lysosomal membrane damage have demonstrated that lysosomal leakage does not necessarily equal cell death. Notably, cells are not only able to survive minor lysosomal membrane permeabilization, but some of their normal functions actually depend on leaked lysosomal hydrolases. Here we discuss emerging data suggesting that spatially and temporally controlled lysosomal leakage delivers lysosomal hydrolases to specific subcellular sites of action and controls at least three essential cellular processes, namely mitotic chromosome segregation, inflammatory signaling, and cellular motility.

KW - Adhesion

KW - Cathepsins

KW - Chromosome segregation

KW - Inflammation

KW - Lysosomal membrane permeabilization

KW - Lysosomal storage disorders

KW - Lysosome

KW - Mitosis

KW - Motility

KW - NLRP3 inflammasome

U2 - 10.1016/j.ceb.2021.02.003

DO - 10.1016/j.ceb.2021.02.003

M3 - Review

C2 - 33684809

AN - SCOPUS:85101972995

VL - 71

SP - 29

EP - 37

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

ER -

ID: 258892394