Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope

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Standard

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope. / Iversen, Astrid K N; Stewart-Jones, Guillaume; Learn, Gerald H; Christie, Natasha; Sylvester-Hviid, Christina; Armitage, Andrew E; Kaul, Rupert; Beattie, Tara; Lee, Jean K; Li, Yanping; Chotiyarnwong, Pojchong; Dong, Tao; Xu, Xiaoning; Luscher, Mark A; MacDonald, Kelly; Ullum, Henrik; Klarlund-Pedersen, Bente; Skinhøj, Peter; Fugger, Lars; Buus, Søren; Mullins, James I; Jones, E Yvonne; van der Merwe, P Anton; McMichael, Andrew J.

I: Nature Immunology, Bind 7, Nr. 2, 2006, s. 179-89.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Iversen, AKN, Stewart-Jones, G, Learn, GH, Christie, N, Sylvester-Hviid, C, Armitage, AE, Kaul, R, Beattie, T, Lee, JK, Li, Y, Chotiyarnwong, P, Dong, T, Xu, X, Luscher, MA, MacDonald, K, Ullum, H, Klarlund-Pedersen, B, Skinhøj, P, Fugger, L, Buus, S, Mullins, JI, Jones, EY, van der Merwe, PA & McMichael, AJ 2006, 'Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope', Nature Immunology, bind 7, nr. 2, s. 179-89. https://doi.org/10.1038/ni1298

APA

Iversen, A. K. N., Stewart-Jones, G., Learn, G. H., Christie, N., Sylvester-Hviid, C., Armitage, A. E., Kaul, R., Beattie, T., Lee, J. K., Li, Y., Chotiyarnwong, P., Dong, T., Xu, X., Luscher, M. A., MacDonald, K., Ullum, H., Klarlund-Pedersen, B., Skinhøj, P., Fugger, L., ... McMichael, A. J. (2006). Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope. Nature Immunology, 7(2), 179-89. https://doi.org/10.1038/ni1298

Vancouver

Iversen AKN, Stewart-Jones G, Learn GH, Christie N, Sylvester-Hviid C, Armitage AE o.a. Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope. Nature Immunology. 2006;7(2):179-89. https://doi.org/10.1038/ni1298

Author

Iversen, Astrid K N ; Stewart-Jones, Guillaume ; Learn, Gerald H ; Christie, Natasha ; Sylvester-Hviid, Christina ; Armitage, Andrew E ; Kaul, Rupert ; Beattie, Tara ; Lee, Jean K ; Li, Yanping ; Chotiyarnwong, Pojchong ; Dong, Tao ; Xu, Xiaoning ; Luscher, Mark A ; MacDonald, Kelly ; Ullum, Henrik ; Klarlund-Pedersen, Bente ; Skinhøj, Peter ; Fugger, Lars ; Buus, Søren ; Mullins, James I ; Jones, E Yvonne ; van der Merwe, P Anton ; McMichael, Andrew J. / Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope. I: Nature Immunology. 2006 ; Bind 7, Nr. 2. s. 179-89.

Bibtex

@article{cf0136a0ebc911ddbf70000ea68e967b,
title = "Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope",
abstract = "Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL epitope and found two principal, diametrically opposed evolutionary pathways that exclusively affect T cell-receptor contact residues. One pathway was characterized by acquisition of CTL escape mutations and the other by selection for wild-type amino acids. The pattern of CTL responses to epitope variants shaped which variant(s) prevailed in the virus population. The pathways notably influenced the amount of plasma virus, as patients with efficient CTL selection had lower plasma viral loads than did patients without efficient selection. Thus, viral escape from CTL responses does not necessarily correlate with disease progression.",
author = "Iversen, {Astrid K N} and Guillaume Stewart-Jones and Learn, {Gerald H} and Natasha Christie and Christina Sylvester-Hviid and Armitage, {Andrew E} and Rupert Kaul and Tara Beattie and Lee, {Jean K} and Yanping Li and Pojchong Chotiyarnwong and Tao Dong and Xiaoning Xu and Luscher, {Mark A} and Kelly MacDonald and Henrik Ullum and Bente Klarlund-Pedersen and Peter Skinh{\o}j and Lars Fugger and S{\o}ren Buus and Mullins, {James I} and Jones, {E Yvonne} and {van der Merwe}, {P Anton} and McMichael, {Andrew J}",
note = "Keywords: Adult; Amino Acid Sequence; Crystallography, X-Ray; Evolution, Molecular; Female; Gene Products, gag; Genetic Variation; HIV Antigens; HIV Infections; HIV-1; HLA-A2 Antigen; Humans; Immunodominant Epitopes; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; Mutation; Peptide Fragments; Phylogeny; Receptors, Antigen, T-Cell; Selection (Genetics); T-Lymphocytes, Cytotoxic; Viremia; env Gene Products, Human Immunodeficiency Virus",
year = "2006",
doi = "10.1038/ni1298",
language = "English",
volume = "7",
pages = "179--89",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope

AU - Iversen, Astrid K N

AU - Stewart-Jones, Guillaume

AU - Learn, Gerald H

AU - Christie, Natasha

AU - Sylvester-Hviid, Christina

AU - Armitage, Andrew E

AU - Kaul, Rupert

AU - Beattie, Tara

AU - Lee, Jean K

AU - Li, Yanping

AU - Chotiyarnwong, Pojchong

AU - Dong, Tao

AU - Xu, Xiaoning

AU - Luscher, Mark A

AU - MacDonald, Kelly

AU - Ullum, Henrik

AU - Klarlund-Pedersen, Bente

AU - Skinhøj, Peter

AU - Fugger, Lars

AU - Buus, Søren

AU - Mullins, James I

AU - Jones, E Yvonne

AU - van der Merwe, P Anton

AU - McMichael, Andrew J

N1 - Keywords: Adult; Amino Acid Sequence; Crystallography, X-Ray; Evolution, Molecular; Female; Gene Products, gag; Genetic Variation; HIV Antigens; HIV Infections; HIV-1; HLA-A2 Antigen; Humans; Immunodominant Epitopes; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; Mutation; Peptide Fragments; Phylogeny; Receptors, Antigen, T-Cell; Selection (Genetics); T-Lymphocytes, Cytotoxic; Viremia; env Gene Products, Human Immunodeficiency Virus

PY - 2006

Y1 - 2006

N2 - Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL epitope and found two principal, diametrically opposed evolutionary pathways that exclusively affect T cell-receptor contact residues. One pathway was characterized by acquisition of CTL escape mutations and the other by selection for wild-type amino acids. The pattern of CTL responses to epitope variants shaped which variant(s) prevailed in the virus population. The pathways notably influenced the amount of plasma virus, as patients with efficient CTL selection had lower plasma viral loads than did patients without efficient selection. Thus, viral escape from CTL responses does not necessarily correlate with disease progression.

AB - Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL epitope and found two principal, diametrically opposed evolutionary pathways that exclusively affect T cell-receptor contact residues. One pathway was characterized by acquisition of CTL escape mutations and the other by selection for wild-type amino acids. The pattern of CTL responses to epitope variants shaped which variant(s) prevailed in the virus population. The pathways notably influenced the amount of plasma virus, as patients with efficient CTL selection had lower plasma viral loads than did patients without efficient selection. Thus, viral escape from CTL responses does not necessarily correlate with disease progression.

U2 - 10.1038/ni1298

DO - 10.1038/ni1298

M3 - Journal article

C2 - 16388312

VL - 7

SP - 179

EP - 189

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 2

ER -

ID: 9942824