Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy
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Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy. / Biccirè, Flavio G.; Häner, Jonas; Losdat, Sylvain; Ueki, Yasushi; Shibutani, Hiroki; Otsuka, Tatsuhiko; Kakizaki, Ryota; Hofbauer, Thomas M.; van Geuns, Robert Jan; Stortecky, Stefan; Siontis, George C.M.; Bär, Sarah; Lønborg, Jacob; Heg, Dik; Kaiser, Christoph; Spirk, David; Daemen, Joost; Iglesias, Juan F.; Windecker, Stephan; Engstrøm, Thomas; Lang, Irene; Koskinas, Konstantinos C.; Räber, Lorenz.
I: Journal of the American College of Cardiology, Bind 82, Nr. 18, 2023, s. 1737-1747.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy
AU - Biccirè, Flavio G.
AU - Häner, Jonas
AU - Losdat, Sylvain
AU - Ueki, Yasushi
AU - Shibutani, Hiroki
AU - Otsuka, Tatsuhiko
AU - Kakizaki, Ryota
AU - Hofbauer, Thomas M.
AU - van Geuns, Robert Jan
AU - Stortecky, Stefan
AU - Siontis, George C.M.
AU - Bär, Sarah
AU - Lønborg, Jacob
AU - Heg, Dik
AU - Kaiser, Christoph
AU - Spirk, David
AU - Daemen, Joost
AU - Iglesias, Juan F.
AU - Windecker, Stephan
AU - Engstrøm, Thomas
AU - Lang, Irene
AU - Koskinas, Konstantinos C.
AU - Räber, Lorenz
N1 - Publisher Copyright: © 2023 American College of Cardiology Foundation
PY - 2023
Y1 - 2023
N2 - Background: The frequency, characteristics, and outcomes of patients treated with high-intensity lipid-lowering therapy and showing concomitant atheroma volume reduction, lipid content reduction, and increase in fibrous cap thickness (ie, triple regression) are unknown. Objectives: This study was designed to investigate rates, determinants, and prognostic implications of triple regression in patients presenting with acute myocardial infarction and treated with high-intensity lipid-lowering therapy. Methods: The PACMAN-AMI (Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction) trial used serial intravascular ultrasound, near-infrared spectroscopy, and optical coherence tomography to compare the effects of alirocumab vs placebo in patients receiving high-intensity statin therapy. Triple regression was defined by the combined presence of percentage of atheroma volume reduction, maximum lipid core burden index within 4 mm reduction, and minimal fibrous cap thickness increase. Clinical outcomes at 1-year follow-up were assessed. Results: Overall, 84 patients (31.7%) showed triple regression (40.8% in the alirocumab group vs 23.0% in the placebo group; P = 0.002). On-treatment low-density lipoprotein cholesterol levels were lower in patients with vs without triple regression (between-group difference: −27.1 mg/dL; 95% CI: −37.7 to −16.6 mg/dL; P < 0.001). Triple regression was independently predicted by alirocumab treatment (OR: 2.83; 95% CI: 1.57-5.16; P = 0.001) and a higher baseline maximum lipid core burden index within 4 mm (OR: 1.03; 95% CI: 1.01-1.06; P = 0.013). The composite clinical endpoint of death, myocardial infarction, and ischemia-driven revascularization occurred less frequently in patients with vs without triple regression (8.3% vs 18.2%; P = 0.04). Conclusions: Triple regression occurred in one-third of patients with acute myocardial infarction who were receiving high-intensity lipid-lowering therapy and was associated with alirocumab treatment, higher baseline lipid content, and reduced cardiovascular events. (Vascular Effects of Alirocumab in Acute MI-Patients [PACMAN-AMI]; NCT03067844)
AB - Background: The frequency, characteristics, and outcomes of patients treated with high-intensity lipid-lowering therapy and showing concomitant atheroma volume reduction, lipid content reduction, and increase in fibrous cap thickness (ie, triple regression) are unknown. Objectives: This study was designed to investigate rates, determinants, and prognostic implications of triple regression in patients presenting with acute myocardial infarction and treated with high-intensity lipid-lowering therapy. Methods: The PACMAN-AMI (Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction) trial used serial intravascular ultrasound, near-infrared spectroscopy, and optical coherence tomography to compare the effects of alirocumab vs placebo in patients receiving high-intensity statin therapy. Triple regression was defined by the combined presence of percentage of atheroma volume reduction, maximum lipid core burden index within 4 mm reduction, and minimal fibrous cap thickness increase. Clinical outcomes at 1-year follow-up were assessed. Results: Overall, 84 patients (31.7%) showed triple regression (40.8% in the alirocumab group vs 23.0% in the placebo group; P = 0.002). On-treatment low-density lipoprotein cholesterol levels were lower in patients with vs without triple regression (between-group difference: −27.1 mg/dL; 95% CI: −37.7 to −16.6 mg/dL; P < 0.001). Triple regression was independently predicted by alirocumab treatment (OR: 2.83; 95% CI: 1.57-5.16; P = 0.001) and a higher baseline maximum lipid core burden index within 4 mm (OR: 1.03; 95% CI: 1.01-1.06; P = 0.013). The composite clinical endpoint of death, myocardial infarction, and ischemia-driven revascularization occurred less frequently in patients with vs without triple regression (8.3% vs 18.2%; P = 0.04). Conclusions: Triple regression occurred in one-third of patients with acute myocardial infarction who were receiving high-intensity lipid-lowering therapy and was associated with alirocumab treatment, higher baseline lipid content, and reduced cardiovascular events. (Vascular Effects of Alirocumab in Acute MI-Patients [PACMAN-AMI]; NCT03067844)
KW - acute coronary syndromes
KW - atherosclerosis
KW - intravascular ultrasound
KW - lipid lowering
KW - optical coherence tomography, PCSK9 inhibitors
U2 - 10.1016/j.jacc.2023.08.019
DO - 10.1016/j.jacc.2023.08.019
M3 - Journal article
C2 - 37640248
AN - SCOPUS:85173965632
VL - 82
SP - 1737
EP - 1747
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 18
ER -
ID: 396989535