Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration
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Concise Review : Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration. / Rumman, Mohammad; Dhawan, Jyotsna; Kassem, Moustapha.
I: Stem Cells, Bind 33, Nr. 10, 10.2015, s. 2903-12.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Concise Review
T2 - Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration
AU - Rumman, Mohammad
AU - Dhawan, Jyotsna
AU - Kassem, Moustapha
N1 - © 2015 AlphaMed Press.
PY - 2015/10
Y1 - 2015/10
N2 - Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.
AB - Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.
KW - Adult Stem Cells
KW - Cell Cycle Checkpoints
KW - Cell Differentiation
KW - Homeostasis
KW - Humans
KW - Regeneration
KW - Wound Healing
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1002/stem.2056
DO - 10.1002/stem.2056
M3 - Journal article
C2 - 26075660
VL - 33
SP - 2903
EP - 2912
JO - Stem Cells
JF - Stem Cells
SN - 1066-5099
IS - 10
ER -
ID: 176343218