Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies - where are we now?
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Concise review : bridging the gap: bone regeneration using skeletal stem cell-based strategies - where are we now? / Dawson, Jonathan I; Kanczler, Janos; Tare, Rahul; Kassem, Moustapha; Oreffo, Richard O C.
I: Stem Cells, Bind 32, Nr. 1, 01.2014, s. 35-44.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Concise review
T2 - bridging the gap: bone regeneration using skeletal stem cell-based strategies - where are we now?
AU - Dawson, Jonathan I
AU - Kanczler, Janos
AU - Tare, Rahul
AU - Kassem, Moustapha
AU - Oreffo, Richard O C
N1 - © 2013 AlphaMed Press.
PY - 2014/1
Y1 - 2014/1
N2 - Skeletal stem cells confer to bone its innate capacity for regeneration and repair. Bone regeneration strategies seek to harness and enhance this regenerative capacity for the replacement of tissue damaged or lost through congenital defects, trauma, functional/esthetic problems, and a broad range of diseases associated with an increasingly aged population. This review describes the state of the field and current steps to translate and apply skeletal stem cell biology in the clinic and the problems therein. Challenges are described along with key strategies including the isolation and ex vivo expansion of multipotential populations, the targeting/delivery of regenerative populations to sites of repair, and their differentiation toward bone lineages. Finally, preclinical models of bone repair are discussed along with their implications for clinical translation and the opportunities to harness that knowledge for musculoskeletal regeneration.
AB - Skeletal stem cells confer to bone its innate capacity for regeneration and repair. Bone regeneration strategies seek to harness and enhance this regenerative capacity for the replacement of tissue damaged or lost through congenital defects, trauma, functional/esthetic problems, and a broad range of diseases associated with an increasingly aged population. This review describes the state of the field and current steps to translate and apply skeletal stem cell biology in the clinic and the problems therein. Challenges are described along with key strategies including the isolation and ex vivo expansion of multipotential populations, the targeting/delivery of regenerative populations to sites of repair, and their differentiation toward bone lineages. Finally, preclinical models of bone repair are discussed along with their implications for clinical translation and the opportunities to harness that knowledge for musculoskeletal regeneration.
KW - Animals
KW - Bone Regeneration
KW - Cell Differentiation
KW - Humans
KW - Muscle, Skeletal
KW - Regenerative Medicine
KW - Stem Cell Transplantation
KW - Stem Cells
KW - Tissue Engineering
U2 - 10.1002/stem.1559
DO - 10.1002/stem.1559
M3 - Journal article
C2 - 24115290
VL - 32
SP - 35
EP - 44
JO - Stem Cells
JF - Stem Cells
SN - 1066-5099
IS - 1
ER -
ID: 160162117