Computed tomography quantification of emphysema in people living with HIV and uninfected controls

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Computed tomography quantification of emphysema in people living with HIV and uninfected controls. / Ronit, Andreas; Kristensen, Thomas; Hoseth, Vilde S; Abou-Kassem, Dalia; Kühl, Jørgen T; Benfield, Thomas; Gerstoft, Jan; Afzal, Shoaib; Nordestgaard, Børge G; Lundgren, Jens D; Vestbo, Jørgen; Kofoed, Klaus F; Nielsen, Susanne D; Copenhagen Comorbidity in HIV Infection (COCOMO) study group.

I: The European Respiratory Journal, Bind 52, Nr. 1, 1800296, 2018.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ronit, A, Kristensen, T, Hoseth, VS, Abou-Kassem, D, Kühl, JT, Benfield, T, Gerstoft, J, Afzal, S, Nordestgaard, BG, Lundgren, JD, Vestbo, J, Kofoed, KF, Nielsen, SD & Copenhagen Comorbidity in HIV Infection (COCOMO) study group 2018, 'Computed tomography quantification of emphysema in people living with HIV and uninfected controls', The European Respiratory Journal, bind 52, nr. 1, 1800296. https://doi.org/10.1183/13993003.00296-2018

APA

Ronit, A., Kristensen, T., Hoseth, V. S., Abou-Kassem, D., Kühl, J. T., Benfield, T., Gerstoft, J., Afzal, S., Nordestgaard, B. G., Lundgren, J. D., Vestbo, J., Kofoed, K. F., Nielsen, S. D., & Copenhagen Comorbidity in HIV Infection (COCOMO) study group (2018). Computed tomography quantification of emphysema in people living with HIV and uninfected controls. The European Respiratory Journal, 52(1), [1800296]. https://doi.org/10.1183/13993003.00296-2018

Vancouver

Ronit A, Kristensen T, Hoseth VS, Abou-Kassem D, Kühl JT, Benfield T o.a. Computed tomography quantification of emphysema in people living with HIV and uninfected controls. The European Respiratory Journal. 2018;52(1). 1800296. https://doi.org/10.1183/13993003.00296-2018

Author

Ronit, Andreas ; Kristensen, Thomas ; Hoseth, Vilde S ; Abou-Kassem, Dalia ; Kühl, Jørgen T ; Benfield, Thomas ; Gerstoft, Jan ; Afzal, Shoaib ; Nordestgaard, Børge G ; Lundgren, Jens D ; Vestbo, Jørgen ; Kofoed, Klaus F ; Nielsen, Susanne D ; Copenhagen Comorbidity in HIV Infection (COCOMO) study group. / Computed tomography quantification of emphysema in people living with HIV and uninfected controls. I: The European Respiratory Journal. 2018 ; Bind 52, Nr. 1.

Bibtex

@article{c34adefc1f4748df8a6a75cd3a69f3b5,

title = "Computed tomography quantification of emphysema in people living with HIV and uninfected controls",

abstract = "People living with HIV (PLWH) may be more susceptible to the development of emphysema than uninfected individuals. We assessed prevalence and risk factors for emphysema in PLWH and uninfected controls. Spirometry and chest computed tomography scans were obtained in PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and in uninfected controls from the Copenhagen General Population Study (CGPS) who were >40 years. Emphysema was quantified using a low attenuation area < -950 Hounsfield units (%LAA-950) and the 15th percentile density index (PD15) and assessed by semi-quantitative visual scales. Of 742 PLWH, 21.2% and 4.7% had emphysema according to the %LAA-950 threshold with cut-offs at 5% and 10%, respectively. Of 470 uninfected controls, these numbers were 24.3% (p=0.23) and 4.0% (p=0.68). HIV was not associated with emphysema (adjusted OR 1.25, 95% CI 0.68-2.36 for %LAA-950 >10%) by PD15 or by visually assessed emphysema. We found no interaction between HIV and cumulative smoking. Breathlessness and sputum production were more common in PLWH with emphysema, and emphysema seemed to be more prevalent in PLWH with airflow limitation. HIV was therefore not independently associated with emphysema, but the clinical impact of emphysema was greater in PLWH than in uninfected controls.",

author = "Andreas Ronit and Thomas Kristensen and Hoseth, {Vilde S} and Dalia Abou-Kassem and K{\"u}hl, {J{\o}rgen T} and Thomas Benfield and Jan Gerstoft and Shoaib Afzal and Nordestgaard, {B{\o}rge G} and Lundgren, {Jens D} and J{\o}rgen Vestbo and Kofoed, {Klaus F} and Nielsen, {Susanne D} and {Copenhagen Comorbidity in HIV Infection (COCOMO) study group}",

note = "Copyright {\textcopyright}ERS 2018.",

year = "2018",

doi = "10.1183/13993003.00296-2018",

language = "English",

volume = "52",

journal = "The European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "1",

}

RIS

TY - JOUR

T1 - Computed tomography quantification of emphysema in people living with HIV and uninfected controls

AU - Ronit, Andreas

AU - Kristensen, Thomas

AU - Hoseth, Vilde S

AU - Abou-Kassem, Dalia

AU - Kühl, Jørgen T

AU - Benfield, Thomas

AU - Gerstoft, Jan

AU - Afzal, Shoaib

AU - Nordestgaard, Børge G

AU - Lundgren, Jens D

AU - Vestbo, Jørgen

AU - Kofoed, Klaus F

AU - Nielsen, Susanne D

AU - Copenhagen Comorbidity in HIV Infection (COCOMO) study group

PY - 2018

Y1 - 2018

N2 - People living with HIV (PLWH) may be more susceptible to the development of emphysema than uninfected individuals. We assessed prevalence and risk factors for emphysema in PLWH and uninfected controls. Spirometry and chest computed tomography scans were obtained in PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and in uninfected controls from the Copenhagen General Population Study (CGPS) who were >40 years. Emphysema was quantified using a low attenuation area < -950 Hounsfield units (%LAA-950) and the 15th percentile density index (PD15) and assessed by semi-quantitative visual scales. Of 742 PLWH, 21.2% and 4.7% had emphysema according to the %LAA-950 threshold with cut-offs at 5% and 10%, respectively. Of 470 uninfected controls, these numbers were 24.3% (p=0.23) and 4.0% (p=0.68). HIV was not associated with emphysema (adjusted OR 1.25, 95% CI 0.68-2.36 for %LAA-950 >10%) by PD15 or by visually assessed emphysema. We found no interaction between HIV and cumulative smoking. Breathlessness and sputum production were more common in PLWH with emphysema, and emphysema seemed to be more prevalent in PLWH with airflow limitation. HIV was therefore not independently associated with emphysema, but the clinical impact of emphysema was greater in PLWH than in uninfected controls.

AB - People living with HIV (PLWH) may be more susceptible to the development of emphysema than uninfected individuals. We assessed prevalence and risk factors for emphysema in PLWH and uninfected controls. Spirometry and chest computed tomography scans were obtained in PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and in uninfected controls from the Copenhagen General Population Study (CGPS) who were >40 years. Emphysema was quantified using a low attenuation area < -950 Hounsfield units (%LAA-950) and the 15th percentile density index (PD15) and assessed by semi-quantitative visual scales. Of 742 PLWH, 21.2% and 4.7% had emphysema according to the %LAA-950 threshold with cut-offs at 5% and 10%, respectively. Of 470 uninfected controls, these numbers were 24.3% (p=0.23) and 4.0% (p=0.68). HIV was not associated with emphysema (adjusted OR 1.25, 95% CI 0.68-2.36 for %LAA-950 >10%) by PD15 or by visually assessed emphysema. We found no interaction between HIV and cumulative smoking. Breathlessness and sputum production were more common in PLWH with emphysema, and emphysema seemed to be more prevalent in PLWH with airflow limitation. HIV was therefore not independently associated with emphysema, but the clinical impact of emphysema was greater in PLWH than in uninfected controls.

U2 - 10.1183/13993003.00296-2018

DO - 10.1183/13993003.00296-2018

M3 - Journal article

C2 - 29880654

VL - 52

JO - The European Respiratory Journal

JF - The European Respiratory Journal

SN - 0903-1936

IS - 1

M1 - 1800296

ER -

ID: 213363829