Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy
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Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy. / Madsen, Jasmine Melissa; Glinge, Charlotte; Jabbari, Reza; Nepper-Christensen, Lars; Hofsten, Dan Eik; Tilsted, Hans-Henrik; Holmvang, Lene; Pedersen, Frants; Joshi, Francis Richard; Sørensen, Rikke; Bang, Lia Evi; Botker, Hans Erik; Terkelsen, Christian Juhl; Maeng, Michael; Jensen, Lisette Okkels; Aaroe, Jens; Kelbaek, Henning; Torp-Pedersen, Christian; Køber, Lars; Lonborg, Jacob Thomsen; Engstrøm, Thomas.
I: American Journal of Cardiology, Bind 166, 2022, s. 18-24.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy
AU - Madsen, Jasmine Melissa
AU - Glinge, Charlotte
AU - Jabbari, Reza
AU - Nepper-Christensen, Lars
AU - Hofsten, Dan Eik
AU - Tilsted, Hans-Henrik
AU - Holmvang, Lene
AU - Pedersen, Frants
AU - Joshi, Francis Richard
AU - Sørensen, Rikke
AU - Bang, Lia Evi
AU - Botker, Hans Erik
AU - Terkelsen, Christian Juhl
AU - Maeng, Michael
AU - Jensen, Lisette Okkels
AU - Aaroe, Jens
AU - Kelbaek, Henning
AU - Torp-Pedersen, Christian
AU - Køber, Lars
AU - Lonborg, Jacob Thomsen
AU - Engstrøm, Thomas
PY - 2022
Y1 - 2022
N2 - In patients with ST-segment elevation myocardial infarction (STEMI), ischemic postconditioning (iPOST) have shown ambiguous results in minimizing reperfusion injury. Previous findings show beneficial effects of iPOST in patients with STEMI treated without thrombectomy. However, it remains unknown whether the cardioprotective effect of iPOST in these patients persist on long term. In the current study, all patients were identified through the DANAMI-3-iPOST database. Patients were randomized to conventional primary percutaneous coronary intervention (PCI) or iPOST in addition to PCI. Cumulative incidence rates were calculated, and multivariable analyses stratified according to thrombectomy use were performed. The primary end point was a combination of cardiovascular mortality and hospitalization for heart failure. From 2011 to 2014, 1,234 patients with STEMI were included with a median follow-up of 4.8 years. In patients treated without thrombectomy (n = 520), the primary end point occurred in 15% (48/326) in the iPOST group and in 22% (42/194) in the conventional group (unadjusted hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.41 to 0.94, p = 0.023). In adjusted Cox analysis, iPOST remained associated with reduced long-term risk of cardiovascular mortality (HR 0.53, 95% CI 0.29 to 0.97, p = 0.039). In patients treated with thrombectomy (n = 714), there was no significant difference between iPOST (17%, 49/291) and conventional treatment (17%, 72/423) on the primary end point (unadjusted HR 1.01, 95% CI 0.70 to 1.45, p = 0.95). During a follow-up of nearly 5 years, iPOST reduced long-term occurrence of cardiovascular mortality and hospitalization for heart failure in patients with STEMI treated with PCI but without thrombectomy. (C) 2021 The Author(s). Published by Elsevier Inc.
AB - In patients with ST-segment elevation myocardial infarction (STEMI), ischemic postconditioning (iPOST) have shown ambiguous results in minimizing reperfusion injury. Previous findings show beneficial effects of iPOST in patients with STEMI treated without thrombectomy. However, it remains unknown whether the cardioprotective effect of iPOST in these patients persist on long term. In the current study, all patients were identified through the DANAMI-3-iPOST database. Patients were randomized to conventional primary percutaneous coronary intervention (PCI) or iPOST in addition to PCI. Cumulative incidence rates were calculated, and multivariable analyses stratified according to thrombectomy use were performed. The primary end point was a combination of cardiovascular mortality and hospitalization for heart failure. From 2011 to 2014, 1,234 patients with STEMI were included with a median follow-up of 4.8 years. In patients treated without thrombectomy (n = 520), the primary end point occurred in 15% (48/326) in the iPOST group and in 22% (42/194) in the conventional group (unadjusted hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.41 to 0.94, p = 0.023). In adjusted Cox analysis, iPOST remained associated with reduced long-term risk of cardiovascular mortality (HR 0.53, 95% CI 0.29 to 0.97, p = 0.039). In patients treated with thrombectomy (n = 714), there was no significant difference between iPOST (17%, 49/291) and conventional treatment (17%, 72/423) on the primary end point (unadjusted HR 1.01, 95% CI 0.70 to 1.45, p = 0.95). During a follow-up of nearly 5 years, iPOST reduced long-term occurrence of cardiovascular mortality and hospitalization for heart failure in patients with STEMI treated with PCI but without thrombectomy. (C) 2021 The Author(s). Published by Elsevier Inc.
KW - OPEN-LABEL
KW - REPERFUSION
KW - REGISTRY
KW - SYSTEM
U2 - 10.1016/j.amjcard.2021.11.014
DO - 10.1016/j.amjcard.2021.11.014
M3 - Journal article
C2 - 34930614
VL - 166
SP - 18
EP - 24
JO - Am. J. Cardiol.
JF - Am. J. Cardiol.
SN - 0002-9149
ER -
ID: 302380877