Common variants at 19p13 are associated with susceptibility to ovarian cancer
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10¿4 and P = 6 × 10¿4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10¿¿ and P = 4 × 10¿¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
Originalsprog | Engelsk |
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Tidsskrift | Nature Genetics |
Vol/bind | 42 |
Udgave nummer | 10 |
Sider (fra-til) | 880-4 |
Antal sider | 5 |
ISSN | 1061-4036 |
DOI | |
Status | Udgivet - 1 okt. 2010 |
ID: 34122243