Common variant at 16p11.2 conferring risk of psychosis

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Common variant at 16p11.2 conferring risk of psychosis. / Steinberg, S; de Jong, S; Mattheisen, M; Costas, J; Demontis, D; Jamain, S; Pietiläinen, O P H; Lin, K; Papiol, S; Huttenlocher, J; Sigurdsson, E; Vassos, E; Giegling, I; Breuer, R; Fraser, G; Walker, N; Melle, I; Djurovic, S; Agartz, I; Tuulio-Henriksson, A; Suvisaari, J; Lönnqvist, J; Paunio, T; Olsen, Line; Hansen, Thomas Folkmann; Ingason, A; Pirinen, M; Strengman, E; Hougaard, D M; Orntoft, T; Didriksen, M; Hollegaard, M V; Nordentoft, M; Abramova, L; Kaleda, V; Arrojo, M; Sanjuán, J; Arango, C; Etain, B; Bellivier, F; Méary, A; Schürhoff, F; Szoke, A; Ribolsi, M; Magni, V; Siracusano, A; Sperling, S; Rossner, M; Christiansen, C; Werge, T; GROUP.

I: Molecular Psychiatry, Bind 19, Nr. 1, 01.2014, s. 108-114.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Steinberg, S, de Jong, S, Mattheisen, M, Costas, J, Demontis, D, Jamain, S, Pietiläinen, OPH, Lin, K, Papiol, S, Huttenlocher, J, Sigurdsson, E, Vassos, E, Giegling, I, Breuer, R, Fraser, G, Walker, N, Melle, I, Djurovic, S, Agartz, I, Tuulio-Henriksson, A, Suvisaari, J, Lönnqvist, J, Paunio, T, Olsen, L, Hansen, TF, Ingason, A, Pirinen, M, Strengman, E, Hougaard, DM, Orntoft, T, Didriksen, M, Hollegaard, MV, Nordentoft, M, Abramova, L, Kaleda, V, Arrojo, M, Sanjuán, J, Arango, C, Etain, B, Bellivier, F, Méary, A, Schürhoff, F, Szoke, A, Ribolsi, M, Magni, V, Siracusano, A, Sperling, S, Rossner, M, Christiansen, C, Werge, T & GROUP 2014, 'Common variant at 16p11.2 conferring risk of psychosis', Molecular Psychiatry, bind 19, nr. 1, s. 108-114. https://doi.org/10.1038/mp.2012.157

APA

Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., Sigurdsson, E., Vassos, E., Giegling, I., Breuer, R., Fraser, G., Walker, N., Melle, I., Djurovic, S., Agartz, I., ... GROUP (2014). Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry, 19(1), 108-114. https://doi.org/10.1038/mp.2012.157

Vancouver

Steinberg S, de Jong S, Mattheisen M, Costas J, Demontis D, Jamain S o.a. Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry. 2014 jan.;19(1):108-114. https://doi.org/10.1038/mp.2012.157

Author

Steinberg, S ; de Jong, S ; Mattheisen, M ; Costas, J ; Demontis, D ; Jamain, S ; Pietiläinen, O P H ; Lin, K ; Papiol, S ; Huttenlocher, J ; Sigurdsson, E ; Vassos, E ; Giegling, I ; Breuer, R ; Fraser, G ; Walker, N ; Melle, I ; Djurovic, S ; Agartz, I ; Tuulio-Henriksson, A ; Suvisaari, J ; Lönnqvist, J ; Paunio, T ; Olsen, Line ; Hansen, Thomas Folkmann ; Ingason, A ; Pirinen, M ; Strengman, E ; Hougaard, D M ; Orntoft, T ; Didriksen, M ; Hollegaard, M V ; Nordentoft, M ; Abramova, L ; Kaleda, V ; Arrojo, M ; Sanjuán, J ; Arango, C ; Etain, B ; Bellivier, F ; Méary, A ; Schürhoff, F ; Szoke, A ; Ribolsi, M ; Magni, V ; Siracusano, A ; Sperling, S ; Rossner, M ; Christiansen, C ; Werge, T ; GROUP. / Common variant at 16p11.2 conferring risk of psychosis. I: Molecular Psychiatry. 2014 ; Bind 19, Nr. 1. s. 108-114.

Bibtex

@article{546cac2c91734619bdd985aa77ec1821,
title = "Common variant at 16p11.2 conferring risk of psychosis",
abstract = "Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).",
keywords = "Adult, Aged, Aged, 80 and over, Bipolar Disorder, Chromosome Aberrations, Chromosomes, Human, Pair 16, Europe, Female, Gene Expression Profiling, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Middle Aged, Odds Ratio, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Risk Factors, Schizophrenia, Young Adult",
author = "S Steinberg and {de Jong}, S and M Mattheisen and J Costas and D Demontis and S Jamain and Pietil{\"a}inen, {O P H} and K Lin and S Papiol and J Huttenlocher and E Sigurdsson and E Vassos and I Giegling and R Breuer and G Fraser and N Walker and I Melle and S Djurovic and I Agartz and A Tuulio-Henriksson and J Suvisaari and J L{\"o}nnqvist and T Paunio and Line Olsen and Hansen, {Thomas Folkmann} and A Ingason and M Pirinen and E Strengman and Hougaard, {D M} and T Orntoft and M Didriksen and Hollegaard, {M V} and M Nordentoft and L Abramova and V Kaleda and M Arrojo and J Sanju{\'a}n and C Arango and B Etain and F Bellivier and A M{\'e}ary and F Sch{\"u}rhoff and A Szoke and M Ribolsi and V Magni and A Siracusano and S Sperling and M Rossner and C Christiansen and T Werge and GROUP",
year = "2014",
month = jan,
doi = "10.1038/mp.2012.157",
language = "English",
volume = "19",
pages = "108--114",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Common variant at 16p11.2 conferring risk of psychosis

AU - Steinberg, S

AU - de Jong, S

AU - Mattheisen, M

AU - Costas, J

AU - Demontis, D

AU - Jamain, S

AU - Pietiläinen, O P H

AU - Lin, K

AU - Papiol, S

AU - Huttenlocher, J

AU - Sigurdsson, E

AU - Vassos, E

AU - Giegling, I

AU - Breuer, R

AU - Fraser, G

AU - Walker, N

AU - Melle, I

AU - Djurovic, S

AU - Agartz, I

AU - Tuulio-Henriksson, A

AU - Suvisaari, J

AU - Lönnqvist, J

AU - Paunio, T

AU - Olsen, Line

AU - Hansen, Thomas Folkmann

AU - Ingason, A

AU - Pirinen, M

AU - Strengman, E

AU - Hougaard, D M

AU - Orntoft, T

AU - Didriksen, M

AU - Hollegaard, M V

AU - Nordentoft, M

AU - Abramova, L

AU - Kaleda, V

AU - Arrojo, M

AU - Sanjuán, J

AU - Arango, C

AU - Etain, B

AU - Bellivier, F

AU - Méary, A

AU - Schürhoff, F

AU - Szoke, A

AU - Ribolsi, M

AU - Magni, V

AU - Siracusano, A

AU - Sperling, S

AU - Rossner, M

AU - Christiansen, C

AU - Werge, T

AU - GROUP

PY - 2014/1

Y1 - 2014/1

N2 - Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).

AB - Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Bipolar Disorder

KW - Chromosome Aberrations

KW - Chromosomes, Human, Pair 16

KW - Europe

KW - Female

KW - Gene Expression Profiling

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - International Cooperation

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Oligonucleotide Array Sequence Analysis

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Schizophrenia

KW - Young Adult

U2 - 10.1038/mp.2012.157

DO - 10.1038/mp.2012.157

M3 - Journal article

C2 - 23164818

VL - 19

SP - 108

EP - 114

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 1

ER -

ID: 138417557