Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes. / Blauw, Lisanne L.; Noordam, Raymond; van der Laan, Sander W.; Trompet, Stella; Kooijman, Sander; van Heemst, Diana; Jukema, Johan Wouter; van Setten, Jessica; de Borst, Gert J.; Tybjærg-Hansen, Anne; Pasterkamp, Gerard; Berbée, Jimmy F.P.; Rensen, Patrick C.N.

I: Journal of Clinical Medicine, Bind 10, Nr. 5, 932, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Blauw, LL, Noordam, R, van der Laan, SW, Trompet, S, Kooijman, S, van Heemst, D, Jukema, JW, van Setten, J, de Borst, GJ, Tybjærg-Hansen, A, Pasterkamp, G, Berbée, JFP & Rensen, PCN 2021, 'Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes', Journal of Clinical Medicine, bind 10, nr. 5, 932. https://doi.org/10.3390/jcm10050932

APA

Blauw, L. L., Noordam, R., van der Laan, S. W., Trompet, S., Kooijman, S., van Heemst, D., Jukema, J. W., van Setten, J., de Borst, G. J., Tybjærg-Hansen, A., Pasterkamp, G., Berbée, J. F. P., & Rensen, P. C. N. (2021). Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes. Journal of Clinical Medicine, 10(5), [932]. https://doi.org/10.3390/jcm10050932

Vancouver

Blauw LL, Noordam R, van der Laan SW, Trompet S, Kooijman S, van Heemst D o.a. Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes. Journal of Clinical Medicine. 2021;10(5). 932. https://doi.org/10.3390/jcm10050932

Author

Blauw, Lisanne L. ; Noordam, Raymond ; van der Laan, Sander W. ; Trompet, Stella ; Kooijman, Sander ; van Heemst, Diana ; Jukema, Johan Wouter ; van Setten, Jessica ; de Borst, Gert J. ; Tybjærg-Hansen, Anne ; Pasterkamp, Gerard ; Berbée, Jimmy F.P. ; Rensen, Patrick C.N. / Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes. I: Journal of Clinical Medicine. 2021 ; Bind 10, Nr. 5.

Bibtex

@article{a62d26363cb34f3d8ad132bc060819b2,
title = "Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes",
abstract = "We analyzed the effects of the common BMI-increasing melanocortin 4 receptor (MC4R) rs17782313-C allele with a minor allele frequency of 0.22–0.25 on (1) cardiovascular disease outcomes in two large population-based cohorts (Copenhagen City Heart Study and Copenhagen General Population Study, n = 106,018; and UK Biobank, n = 357,426) and additionally in an elderly population at risk for cardiovascular disease (n = 5241), and on (2) atherosclerotic plaque phenotypes in samples of patients who underwent endarterectomy (n = 1439). Using regression models, we additionally analyzed whether potential associations were modified by sex or explained by changes in body mass index. We confirmed the BMI-increasing effects of +0.22 kg/m2 per additional copy of the C allele (p < 0.001). However, we found no evidence for an association of common MC4R genetic variation with coronary artery disease (HR 1.03; 95% CI 0.99, 1.07), ischemic vascular disease (HR 1.00; 95% CI 0.98, 1.03), myocardial infarction (HR 1.01; 95% CI 0.94, 1.08 and 1.02; 0.98, 1.07) or stroke (HR 0.93; 95% CI 0.85, 1.01), nor with any atherosclerotic plaque phenotype. Thus, common MC4R genetic variation, despite increasing BMI, does not affect cardiovascular disease risk in the general population or in populations at risk for cardiovascular disease.",
keywords = "Atherosclerosis, BMI, Cardiovascular disease, Genetics, MC4R",
author = "Blauw, {Lisanne L.} and Raymond Noordam and {van der Laan}, {Sander W.} and Stella Trompet and Sander Kooijman and {van Heemst}, Diana and Jukema, {Johan Wouter} and {van Setten}, Jessica and {de Borst}, {Gert J.} and Anne Tybj{\ae}rg-Hansen and Gerard Pasterkamp and Berb{\'e}e, {Jimmy F.P.} and Rensen, {Patrick C.N.}",
note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
doi = "10.3390/jcm10050932",
language = "English",
volume = "10",
journal = "Journal of Clinical Medicine",
issn = "2077-0383",
publisher = "M D P I AG",
number = "5",

}

RIS

TY - JOUR

T1 - Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes

AU - Blauw, Lisanne L.

AU - Noordam, Raymond

AU - van der Laan, Sander W.

AU - Trompet, Stella

AU - Kooijman, Sander

AU - van Heemst, Diana

AU - Jukema, Johan Wouter

AU - van Setten, Jessica

AU - de Borst, Gert J.

AU - Tybjærg-Hansen, Anne

AU - Pasterkamp, Gerard

AU - Berbée, Jimmy F.P.

AU - Rensen, Patrick C.N.

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - We analyzed the effects of the common BMI-increasing melanocortin 4 receptor (MC4R) rs17782313-C allele with a minor allele frequency of 0.22–0.25 on (1) cardiovascular disease outcomes in two large population-based cohorts (Copenhagen City Heart Study and Copenhagen General Population Study, n = 106,018; and UK Biobank, n = 357,426) and additionally in an elderly population at risk for cardiovascular disease (n = 5241), and on (2) atherosclerotic plaque phenotypes in samples of patients who underwent endarterectomy (n = 1439). Using regression models, we additionally analyzed whether potential associations were modified by sex or explained by changes in body mass index. We confirmed the BMI-increasing effects of +0.22 kg/m2 per additional copy of the C allele (p < 0.001). However, we found no evidence for an association of common MC4R genetic variation with coronary artery disease (HR 1.03; 95% CI 0.99, 1.07), ischemic vascular disease (HR 1.00; 95% CI 0.98, 1.03), myocardial infarction (HR 1.01; 95% CI 0.94, 1.08 and 1.02; 0.98, 1.07) or stroke (HR 0.93; 95% CI 0.85, 1.01), nor with any atherosclerotic plaque phenotype. Thus, common MC4R genetic variation, despite increasing BMI, does not affect cardiovascular disease risk in the general population or in populations at risk for cardiovascular disease.

AB - We analyzed the effects of the common BMI-increasing melanocortin 4 receptor (MC4R) rs17782313-C allele with a minor allele frequency of 0.22–0.25 on (1) cardiovascular disease outcomes in two large population-based cohorts (Copenhagen City Heart Study and Copenhagen General Population Study, n = 106,018; and UK Biobank, n = 357,426) and additionally in an elderly population at risk for cardiovascular disease (n = 5241), and on (2) atherosclerotic plaque phenotypes in samples of patients who underwent endarterectomy (n = 1439). Using regression models, we additionally analyzed whether potential associations were modified by sex or explained by changes in body mass index. We confirmed the BMI-increasing effects of +0.22 kg/m2 per additional copy of the C allele (p < 0.001). However, we found no evidence for an association of common MC4R genetic variation with coronary artery disease (HR 1.03; 95% CI 0.99, 1.07), ischemic vascular disease (HR 1.00; 95% CI 0.98, 1.03), myocardial infarction (HR 1.01; 95% CI 0.94, 1.08 and 1.02; 0.98, 1.07) or stroke (HR 0.93; 95% CI 0.85, 1.01), nor with any atherosclerotic plaque phenotype. Thus, common MC4R genetic variation, despite increasing BMI, does not affect cardiovascular disease risk in the general population or in populations at risk for cardiovascular disease.

KW - Atherosclerosis

KW - BMI

KW - Cardiovascular disease

KW - Genetics

KW - MC4R

U2 - 10.3390/jcm10050932

DO - 10.3390/jcm10050932

M3 - Journal article

C2 - 33804309

AN - SCOPUS:85114071439

VL - 10

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 5

M1 - 932

ER -

ID: 279821054